Evidence map›Paper›PMID 33777141›Full record

ArticleInternational journal of endocrinology2021

Association between 25-Hydroxyvitamin D and Metabolic Syndrome in Older Adults: The Health, Aging and Body Composition Study.

Subhashish Agarwal, Janet A Tooze, Douglas C Bauer, Jane A Cauley, Tamara B Harris, Annemarie Koster, Catherine R Womack, Stephen B Kritchevsky, Denise K Houston

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Subhashish AgarwalDepartment of Cardiology, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID https://orcid.org/0000-0002-3154-2924
Janet A ToozeDivision of Public Health Sciences and Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Douglas C BauerGeneral Internal Medicine, University of California San Francisco, San Francisco, CA, USA.
Jane A CauleyDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Tamara B HarrisLaboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA.
Annemarie KosterDepartment of Social Medicine, University of Maastricht, Maastricht, Netherlands.
Catherine R WomackDepartment of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Stephen B KritchevskySticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Denise K HoustonFor the Health ABC Study, Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Wake Forest University · USMaastricht University · NLMedical College of Wisconsin · USNational Institute on Aging · USUniversity of California, San Francisco · USUniversity of Pittsburgh · USUniversity of Tennessee Health Science Center · US

Funding

CVD Epidemiology Training ProgramT32HL076132 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DAVID McLeod HERRINGTON · 2004 to 2026
$8.4M
Peripheral Nerve Function Decline in an Aged CohortR01AG028050 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STROTMEYER, ELSA S. · 2007 to 2015
$3.5M
End of Life in the Very OldR01NR012459 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALBERT, STEVEN M, LUNNEY, JUNE R · 2011 to 2015
$2.7M
Vitamin D, falls, fractures and function in community-dwelling older adultsR01AG029364 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KRITCHEVSKY, STEPHEN B. · 2007 to 2009
$1.5M
NHLBI NIH HHS T32 HL076132NIA NIH HHS R01 AG028050NIA NIH HHS R01 AG029364NINR NIH HHS R01 NR012459
6 · The paper itself

Abstract

objectiveLow 25-hydroxyvitamin D (25[OH]D) levels and metabolic syndrome (MetS) are prevalent among older adults; however, longitudinal studies examining 25(OH)D status and MetS are lacking. We explore the association of 25(OH)D levels with prevalent and incident MetS in white and black older adults.

resultsAt baseline, 635 (39%) white and 363 (36%) black participants had prevalent MetS. In whites, low 25(OH)D levels were associated with prevalent MetS (adjusted OR (95% CI), 1.85 (1.47, 2.34)) and 1.96 (1.46, 2.63) for 25(OH)D of 20-<30 and <20 vs. ≥30 ng/ml, respectively). The association was attenuated after adjustment for BMI but remained significant. No association was found between 25(OH)D levels and prevalent MetS in blacks. Among those without MetS at baseline (765 whites, 427 blacks), 150 (20%) whites and 87 (20%) blacks had developed MetS at 6-year follow-up. However, 25(OH)D levels were not associated with incident MetS in whites or blacks.

conclusionIn older adults, low 25(OH)D levels were associated with increased odds of prevalent MetS in whites but not in blacks. No association was observed between 25(OH)D levels and incident MetS in either whites or blacks.

Identifiers

PMID33777141
PMCPMC7981173
OpenAlexW3137302871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.