Evidence map›Paper›PMID 33777122›Full record

ArticleJournal of otology2021

Clinical trials in otology: Examining trends and framework for prioritization.

Jake Altshuler, Rohan Viswanathan, Divya B Dasani, Katherine Webb, Tam Ramsey, Varun Patel, Randall Ruffner, Jason Mouzakes, David Foyt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of otology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jake AltshulerDivision of Otolaryngology-Head and Neck Surgery, Albany Medical Center, 50 New Scotland Avenue, Albany, NY, 12208, United States.
Rohan ViswanathanDivision of Otolaryngology-Head and Neck Surgery, Albany Medical Center, 50 New Scotland Avenue, Albany, NY, 12208, United States.
Divya B DasaniDivision of Otolaryngology-Head and Neck Surgery, Albany Medical Center, 50 New Scotland Avenue, Albany, NY, 12208, United States.
Katherine WebbDivision of Otolaryngology-Head and Neck Surgery, Albany Medical Center, 50 New Scotland Avenue, Albany, NY, 12208, United States.
Tam RamseyDivision of Otolaryngology-Head and Neck Surgery, Albany Medical Center, 50 New Scotland Avenue, Albany, NY, 12208, United States.
Varun PatelDivision of Otolaryngology-Head and Neck Surgery, Albany Medical Center, 50 New Scotland Avenue, Albany, NY, 12208, United States.
Randall RuffnerDivision of Otolaryngology-Head and Neck Surgery, Albany Medical Center, 50 New Scotland Avenue, Albany, NY, 12208, United States.
Jason MouzakesDivision of Otolaryngology-Head and Neck Surgery, Albany Medical Center, 50 New Scotland Avenue, Albany, NY, 12208, United States.
David FoytDivision of Otolaryngology-Head and Neck Surgery, Albany Medical Center, 50 New Scotland Avenue, Albany, NY, 12208, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo characterize otologic clinical trials and examine otologic clinical trial trends from 2008 to 2018 using the clinicaltrials.gov database.

methodsData was collected from clinicaltrials.gov and included all clinical trials that focused on otology from 2008 to 2018. Outcome measures include status of trials, funding sources, details regarding otologic conditions studied, and trends in clinical trials.

resultsThere were 992 otology clinical trials from 2008 to 2018.457 (46.1%) were completed and 94 (9.5%) were discontinued. Industry remained the highest (76.5%) contributor to otology clinical trials. The otologic conditions studied, from most common to least common, include hearing loss (40.6%), vestibulopathy (18.8%), tinnitus (18.8%), and otitis media (15.1%). The number of otology clinical trials increased by an average of 12.0 trials per year from 2008 to 2018 (p < 0.001). The number of otology clinical trials focusing on hearing loss and vestibulopathy significantly increased over the studied period (p < 0.001), while those focusing on tinnitus and otitis media did not (p = 0.09 and p = 0.20, respectively). The majority of clinical trials on each of these four conditions focused on treatment options.

conclusionOur study describes trends in otology clinical trials registered on clinicaltrials.gov from 2008 through 2018. The total number of clinical trials over this time period increased significantly, driven by trials investigating hearing loss and vestibulopathy. Furthermore, most clinical trials were industry-sponsored and focused on treatment modalities. Our study provides an outline of otology clinical trials registered in a US web-based database, which may be of use for the development of future clinical trials.

Indexed as

Clinical trialsOtologyOtology trend

Identifiers

PMID33777122
PMCPMC7985013

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.