Evidence map›Paper›PMID 33777099›Full record

ArticleFrontiers in genetics2021

Precision Population Medicine in Primary Care: The Sanford Chip Experience.

Kurt D Christensen, Megan Bell, Carrie L B Zawatsky, Lauren N Galbraith, Robert C Green, Allison M Hutchinson, Leila Jamal, Jessica L LeBlanc, Jennifer R Leonhard, Michelle Moore and 11 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Primary Care Providers' Experiences With an Active Elective Genetic Testing Program.Health education & behavior : the official publication of the Society for Public Health Education · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Attitudes, knowledge, and risk perceptions of patients who received elective genomic testing as a clinical service.Genetics in medicine : official journal of the American College of Medical Genetics · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Pharmacogenomics · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 10 institutions in 1 country.

Kurt D ChristensenCenter for Healthcare Research in Pediatrics, Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, United States.
Megan BellSanford Health Imagenetics, Sioux Falls, SD, United States.
Carrie L B ZawatskyDepartment of Medicine, Brigham and Women's Hospital, Boston, MA, United States.
Lauren N GalbraithCenter for Healthcare Research in Pediatrics, Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, United States.
Robert C GreenBroad Institute of MIT and Harvard, Cambridge, MA, United States.
Allison M HutchinsonSanford Health Imagenetics, Sioux Falls, SD, United States.
Leila JamalNational Cancer Institute, Bethesda, MD, United States.
Jessica L LeBlancCenter for Healthcare Research in Pediatrics, Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, United States.
Jennifer R LeonhardSanford Health Imagenetics, Bemidji, MN, United States.
Michelle MooreSanford Health Imagenetics, Sioux Falls, SD, United States.
Lisa MullineauxMayo Clinic Genomics Laboratory, Rochester, MN, United States.
Natasha PetrySanford Health Imagenetics, Fargo, ND, United States.
Dylan M PlattSanford Health Imagenetics, Sioux Falls, SD, United States.
Sherin ShaabanDepartment of Pathology, University of Utah School of Medicine, Salt Lake City, UT, United States.
April SchultzSanford Health Imagenetics, Sioux Falls, SD, United States.
Bethany D TuckerSanford Health Imagenetics, Sioux Falls, SD, United States.
Joel Van HeukelomSanford Health Imagenetics, Sioux Falls, SD, United States.
Elizabeth WheelerSanford Health Imagenetics, Sioux Falls, SD, United States.
Emilie S ZoltickCenter for Healthcare Research in Pediatrics, Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, United States.
Catherine HajekSanford Health Imagenetics, Sioux Falls, SD, United States.
Imagenetics Metrics Team
Sanford Health · USHarvard Pilgrim Health Care · USUniversity of South Dakota · USAriadne Diagnostics (United States) · USARUP Laboratories (United States) · USBrigham and Women's Hospital · USHarvard University · USMayo Clinic · USNational Institutes of Health · USNorth Dakota State University · US

Funding

Cost-effectiveness of Whole Genome Sequencing of Healthy AdultsK01HG009173 · NHGRI · HARVARD PILGRIM HEALTH CARE, INC. · PI CHRISTENSEN, KURT DEREK · 2016 to 2020
$626k
NHGRI NIH HHS K01 HG009173
6 · The paper itself

Abstract

Genetic testing has the potential to revolutionize primary care, but few health systems have developed the infrastructure to support precision population medicine applications or attempted to evaluate its impact on patient and provider outcomes. In 2018, Sanford Health, the nation's largest rural nonprofit health care system, began offering genetic testing to its primary care patients. To date, more than 11,000 patients have participated in the Sanford Chip Program, over 90% of whom have been identified with at least one informative pharmacogenomic variant, and about 1.5% of whom have been identified with a medically actionable predisposition for disease. This manuscript describes the rationale for offering the Sanford Chip, the programs and infrastructure implemented to support it, and evolving plans for research to evaluate its real-world impact.

Indexed as

decision support systems – clinicalgenetic counselinggenetic testingpharmacogenomic testingprimary health care

Identifiers

PMID33777099
PMCPMC7994529
OpenAlexW3150428172

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.