ArticleFrontiers in genetics2021
A Novel Panel of 43 Insertion/Deletion Loci for Human Identifications of Forensic Degraded DNA Samples: Development and Validation.
Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed.
- Developmental validation of a six-dye Multi-InDels kit for personal identification and paternity testing of highly degraded DNA samples.International journal of legal medicine · 2026Article
- Comprehensive investigation of the Applied BiosystemsInternational journal of legal medicine · 2025Article
- Article
- Systematical explorations of forensic feature and population genetic diversity of the Chinese Mongolian group from northwest ChinaForensic sciences research · 2024Article
- Developmental validation of the AGCU YNFS Y Kit: A new 6-dye multiplex system with 44 Y-STRs and 5 Y-InDels for forensic application.PloS one · 2024Article
- Article
- Article
- Recent advances in forensic biology and forensic DNA typing: INTERPOL review 2019-2022.Forensic science international. Synergy · 2023Article
- Conventional Gel Electrophoresis-Resolvable Insertion/Deletion Markers for Individual Identification and Analysis of Population Genetics in Red-Crowned Cranes in Eastern Hokkaido, Japan.Animals : an open access journal from MDPI · 2022Article
- Insights into AIM-InDel diversities in Yunnan Miao and Hani ethnic groups of China for forensic and population genetic purposes.Hereditas · 2022Article
- Genetic diversity analysis of forty-three insertion/deletion loci for forensic individual identification in Han Chinese from Beijing based on a novel panel.Journal of Zhejiang University. Science. B · 2022Article
- Applications of massively parallel sequencing in forensic genetics.Genetics and molecular biology · 2022Article
- Forensic Feature Exploration and Comprehensive Genetic Insights Into Yugu Ethnic Minority and Northern Han PopulationFrontiers in genetics · 2022Article
- Forensic efficiencies of individual identification, kinship testing and ancestral inference in three Yunnan groups based on a self-developed multiple DIP panel.Frontiers in genetics · 2022Article
- An interpretation of the genetic polymorphism and population genetic background of Ankang Han population via a novel InDel panel.Forensic sciences research · 2022Article
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10 authors.
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Abstract
Insertion/deletion polymorphism is a promising genetic marker in the forensic genetic fields, especially in the forensic application of degraded sample at crime scene. In this research, a novel five-dye multiplex amplification panel containing 43 highly polymorphic Insertion/deletion (InDel) loci and one Amelogenin gene locus is designed and constructed in-house for the individual identification in East Asian populations. The amplicon sizes of 43 InDel loci are less than 200 bp, which help to ensure that full allele profiles can be obtained from degraded DNA sample. A series of optimizations and developmental validations including optimization of PCR conditions, detection efficiency of the degraded and casework samples, sensitivity, reproducibility, precision, tolerance for inhibitors, species specificity and DNA mixtures are performed according to the Scientific Working Group on DNA Analysis Methods (SWGDAM) guideline. The results of the internal validation demonstrated that this novel InDel panel was a reliable, sensitive and accurate system with good tolerances to different inhibitors, and performed the considerable detection efficiency for the degraded or mixed samples, which could be used in the forensic applications.
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