Evidence map›Paper›PMID 33777040›Full record

ArticleFrontiers in immunology2021

The Contact Allergen NiSO

Tessa Höper, Katherina Siewert, Verónica I Dumit, Martin von Bergen, Kristin Schubert, Andrea Haase

Open access · goldAbstract readComparative Study
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Role of Innate Immunity in Allergic Contact Dermatitis: An Update.International journal of molecular sciences · 2023
    Review
  11. Article
  12. Article
  13. Immunological Mechanisms of Metal Allergies and the Nickel-Specific TCR-pMHC Interface.International journal of environmental research and public health · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Tessa HöperDepartment of Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany.
Katherina SiewertDepartment of Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany.
Verónica I DumitDepartment of Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany.
Martin von BergenDepartment of Molecular Systems Biology, Helmholtz-Centre for Environmental Research - UFZ, Leipzig, Germany.
Kristin SchubertDepartment of Molecular Systems Biology, Helmholtz-Centre for Environmental Research - UFZ, Leipzig, Germany.
Andrea HaaseDepartment of Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany.
Federal Institute for Risk Assessment · DEFreie Universität Berlin · DEHelmholtz Centre for Environmental Research · DELeipzig University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells (DC) play a central role in the pathogenesis of allergic contact dermatitis (ACD), the most prevalent form of immunotoxicity in humans. However, knowledge on allergy-induced DC maturation is still limited and proteomic studies, allowing to unravel molecular effects of allergens, remain scarce. Therefore, we conducted a global proteomic analysis of human monocyte-derived dendritic cells (MoDC) treated with NiSO

Indexed as

Cell ProliferationDendritic CellsDermatitis, Allergic ContactHumansLipopolysaccharidesNF-E2-Related Factor 2NickelSignal TransductionT-LymphocytesToll-Like Receptor 4Triggering Receptor Expressed on Myeloid Cells-1Up-RegulationLipopolysaccharidesNFE2L2 protein, humanNF-E2-Related Factor 2Nickelnickel sulfateTLR4 protein, humanToll-Like Receptor 4TREM1 protein, humanTriggering Receptor Expressed on Myeloid Cells-1allergic contact dermatitisLPSmonocyte-derived dendritic cellsnickelproteomics

Identifiers

PMID33777040
PMCPMC7991087
OpenAlexW3134168875

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.