Evidence map›Paper›PMID 33777010›Full record

ArticleFrontiers in immunology2021

Identification and Phenotype of MAIT Cells in Cattle and Their Response to Bacterial Infections.

Matthew D Edmans, Timothy K Connelley, Siddharth Jayaraman, Christina Vrettou, Martin Vordermeier, Jeffrey Y W Mak, Ligong Liu, David P Fairlie, Emmanuel Atangana Maze, Tiphany Chrun and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. A Comprehensive Review of the Bovine Immune Response to Pathogens.International journal of molecular sciences · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. MAIT cells in liver inflammation and fibrosis.Seminars in immunopathology · 2022
    Review
  12. Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 3 countries.

Matthew D EdmansDepartment of Enhanced Host Responses, The Pirbright Institute, Pirbright, United Kingdom.
Timothy K ConnelleyDivision of Infection and Immunity, The Roslin Institute, The University of Edinburgh, Easter Bush, Roslin, United Kingdom.
Siddharth JayaramanDivision of Infection and Immunity, The Roslin Institute, The University of Edinburgh, Easter Bush, Roslin, United Kingdom.
Christina VrettouDivision of Infection and Immunity, The Roslin Institute, The University of Edinburgh, Easter Bush, Roslin, United Kingdom.
Martin VordermeierAnimal and Plant Health Agency, Weybridge, United Kingdom.
Jeffrey Y W MakDivision of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Ligong LiuDivision of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
David P FairlieDivision of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Emmanuel Atangana MazeDepartment of Enhanced Host Responses, The Pirbright Institute, Pirbright, United Kingdom.
Tiphany ChrunDepartment of Enhanced Host Responses, The Pirbright Institute, Pirbright, United Kingdom.
Paul KlenermanPeter Medawar Building for Pathogen Research, University of Oxford, Oxford, United Kingdom.
Sidonia B G EckleDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.
Elma TchilianDepartment of Enhanced Host Responses, The Pirbright Institute, Pirbright, United Kingdom.
Lindert BenedictusDivision of Infection and Immunity, The Roslin Institute, The University of Edinburgh, Easter Bush, Roslin, United Kingdom.
The Pirbright Institute · GBUniversity of Edinburgh · GBUniversity of Queensland · AUAnimal and Plant Health Agency · GBAustralian Research Council · AUMedawar Building for Pathogen Research · GBPeter Doherty Institute · AURoslin Institute · GBUtrecht University · NL

Funding

Investigating the basis of MAIT cell antigen potencyR01AI148407 · NIAID · UNIVERSITY OF MELBOURNE · PI MCCLUSKEY, JAMES · 2020 to 2024
$2.7M
Biotechnology and Biological Sciences Research Council BB N004647/1Biotechnology and Biological Sciences Research Council BBS/E/I/00007031Biotechnology and Biological Sciences Research Council BBS/E/I/00007038Biotechnology and Biological Sciences Research Council BBS/E/I/00007039Department of HealthNIAID NIH HHS R01 AI148407Wellcome Trust 109965/Z/15/ZWellcome Trust WT109965MA
6 · The paper itself

Abstract

Mucosal-associated invariant T (MAIT) cells are a population of innate-like T cells that utilize a semi-invariant T cell receptor (TCR) α chain and are restricted by the highly conserved antigen presenting molecule MR1. MR1 presents microbial riboflavin biosynthesis derived metabolites produced by bacteria and fungi. Consistent with their ability to sense ligands derived from bacterial sources, MAIT cells have been associated with the immune response to a variety of bacterial infections, such as

Indexed as

AnimalsBacterial InfectionsCattleCytokinesFemaleHistocompatibility Antigens Class IHumansMaleMiceMinor Histocompatibility AntigensMucosal-Associated Invariant T CellsPhenotypeRibitolUracil5-(2-oxopropylideneamino)-6-d-ribitylaminouracilCytokinesHistocompatibility Antigens Class IMinor Histocompatibility AntigensRibitolUracilbovine tuberculosiscattlemastitisMR1 tetramermucosal-associated invariant T cellsT cell receptorunconventional T cell

Identifiers

PMID33777010
PMCPMC7991102
OpenAlexW3136106493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.