Trial reportFrontiers in immunology2021
The Cholinergic Drug Galantamine Alleviates Oxidative Stress Alongside Anti-inflammatory and Cardio-Metabolic Effects in Subjects With the Metabolic Syndrome in a Randomized Trial.
Open access · goldAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Association between Short-Term Exposure to Ozone and Heart Rate Variability: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Enhanced parasympathetic cholinergic activity with galantamine inhibited lipid-induced oxidative stress in obese African Americans.Molecular medicine (Cambridge, Mass.) · 2022Trial
- The Cholinergic Drug Galantamine Alleviates Oxidative Stress Alongside Anti-inflammatory and Cardio-Metabolic Effects in Subjects With the Metabolic Syndrome in a Randomized Trial.Frontiers in immunology · 2021Trial
- Rewiring mTOR signaling in Alzheimer's disease: emerging mTOR modulators beyond oncology.Bioscience reports · 2026Review
- Acetylcholinesterase inhibitor therapy mitigates hypertension in lupus mice.Clinical science (London, England : 1979) · 2026Article
- Osteocalcin Beyond Bone: Molecular Mechanisms, Endocrine Networks, and Translational Perspectives Across Metabolism, Neurobiology, and Chronic Disease.International journal of molecular sciences · 2026Review
- The cholinergic drug galantamine ameliorates acute and subacute peripheral and brain manifestations of acute respiratory distress syndrome in mice.Scientific reports · 2025Article
- Article
- Biomarkers and Seaweed-Based Nutritional Interventions in Metabolic Syndrome: A Comprehensive Review.Marine drugs · 2024Review
- Integrated approach to reducing polypharmacy in older people: exploring the role of oxidative stress and antioxidant potential therapy.Redox report : communications in free radical research · 2024Review
- Donepezil improves skeletal muscle insulin resistance in obese mice via the AMPK/FGF21-mediated suppression of inflammation and ferroptosis.Archives of pharmacal research · 2024Article
- Acetylcholinesterase Inhibitor Ameliorates Early Cardiometabolic Disorders in Fructose-Overloaded Rat Offspring.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Neuro-Adipokine Crosstalk in Alzheimer's Disease.International journal of molecular sciences · 2024Review
- Cholinergic Stimulation Exerts Cardioprotective Effects and Alleviates Renal Inflammatory Responses after Acute Myocardial Infarction in Spontaneous Hypertensive Rats (SHRs).Pharmaceuticals (Basel, Switzerland) · 2024Article
- Galantamine ameliorates experimental pancreatitis.Molecular medicine (Cambridge, Mass.) · 2023Article
- Neuroimmune nexus in the pathophysiology and therapy of inflammatory disorders: Role of α7 nicotinic acetylcholine receptors.Pharmacological research · 2023Review
- Mechanisms of Oxidative Stress in Metabolic Syndrome.International journal of molecular sciences · 2023Review
- Brief periods of transcutaneous auricular vagus nerve stimulation improve autonomic balance and alter circulating monocytes and endothelial cells in patients with metabolic syndrome: a pilot study.Bioelectronic medicine · 2023Article
- Action of the Purinergic and Cholinergic Anti-inflammatory Pathways on Oxidative Stress in Patients with Alzheimer's Disease in the Context of the COVID-19 Pandemic.Neuroscience · 2023Review
- Peripheral and central macrophages in obesity.Frontiers in endocrinology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 6 institutions in 3 countries.
Carine Teles SangaletiHypertension Unit, University of São Paulo (USP), São Paulo, Brazil.
Keyla Yukari KatayamaNursing Department Graduate Program in Nanosciences and Biosciences, Nove de Julho University (UNINOVE), São Paulo, Brazil.
Kátia De AngelisNursing Department Graduate Program in Nanosciences and Biosciences, Nove de Julho University (UNINOVE), São Paulo, Brazil.
Tércio Lemos de MoraesNursing Department Graduate Program in Nanosciences and Biosciences, Nove de Julho University (UNINOVE), São Paulo, Brazil.
Amanda Aparecida AraújoDepartment of Physiology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Heno F LopesHypertension Unit, University of São Paulo (USP), São Paulo, Brazil.
Cleber CamachoNursing Department Graduate Program in Nanosciences and Biosciences, Nove de Julho University (UNINOVE), São Paulo, Brazil.
Luiz Aparecido BortolottoHypertension Unit, University of São Paulo (USP), São Paulo, Brazil.
Lisete Compagno MicheliniBiomedical Sciences Institute Department of Physiology and Biophysics, University of São Paulo (USP), São Paulo, Brazil.
Maria Cláudia IrigoyenHypertension Unit, University of São Paulo (USP), São Paulo, Brazil.
Peder S OlofssonLaboratory of Immunobiology, Department of Medicine, Center for Bioelectronic Medicine, Karolinska Institutet, Stockholm, Sweden.
Douglas P BarnabyThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, United States.
Kevin J TraceyThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, United States.
Valentin A PavlovThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, United States.
Fernanda Marciano Consolim ColomboHypertension Unit, University of São Paulo (USP), São Paulo, Brazil.
Universidade de São Paulo · BRUniversidade Nove de Julho · BRFeinstein Institute for Medical Research · USNorthwell Health · USUniversidade Federal de São Paulo · BRUniversidade Estadual do Centro-Oeste · BR
Funding
Molecular Basis of Bioelectronic MedicineR35GM118182 · NIGMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI TRACEY, KEVIN J · 2016 to 2025
$7.3MBrainstem Cholinergic Circuitries in the Inflammatory Reflex during SepsisR01GM128008 · NIGMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI PAVLOV, VALENTIN ATANASSOV · 2018 to 2022
$1.8MNIGMS NIH HHS R01 GM128008NIGMS NIH HHS R35 GM118182
Abstract
PubMed holds no abstract for this paper.
Indexed as
AdultAnti-Inflammatory AgentsBiomarkersCholinesterase InhibitorsCytokinesFemaleGalantamineHeart RateHemodynamicsHumansInflammation MediatorsMaleMetabolic SyndromeMetabolomeMiddle AgedMyocardiumAnti-Inflammatory AgentsBiomarkersCholinesterase InhibitorsCytokinesGalantamineInflammation Mediatorsautonomic modulationcholinergicgalantamineheart rate variabilityinflammationmetabolic syndromeoxidative stress
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.