ArticleFrontiers in immunology2021
Immunological Hallmarks of Inflammatory Status in Vaso-Occlusive Crisis of Sickle Cell Anemia Patients.
Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Multidimensional Predictors of Disease Severity and Health Outcomes in Patients with Sickle Cell Disease:Saudi medical journal · 2026Observational
- Cytokine and chemokine signatures of steady-state sickle cell disease in African children: a cross-sectional study.BMC immunology · 2026Article
- G-CSF for Mobilizing CD34American journal of hematology · 2026Article
- Distinct prokaryotic gut microbiome and proviral-immune axes of pathophysiology in Sickle Cell Disease.bioRxiv : the preprint server for biology · 2026Article
- Epidemiological and clinical profile of sickle cell disease in a series of Moroccan children.Journal of community genetics · 2025Article
- Molecular inflammatory expression profiles associated with the frequency of pain in individuals with sickle cell disease.Blood advances · 2025Article
- Cytokine and immune cell interaction in immune-inflammatory response during crisis event in sickle cell disease.African health sciences · 2025Article
- Multidisciplinary approaches to study anaemia with special mention on aplastic anaemia (Review).International journal of molecular medicine · 2024Review
- Role of endothelial dysfunction in sleep-disordered breathing in egyptian children with sickle cell disease.BMC pediatrics · 2024Article
- Effect of Unmetabolized Folic Acid on Immunoinflammatory Markers in Sickle Cell Disease Patients Taking Folic Acid Supplementation.Indian journal of clinical biochemistry : IJCB · 2024Article
- Can we use biomarkers to identify those at risk of acute pain from sickle cell disease?Expert review of hematology · 2024Review
- Article
- Review
- Colchicine reduces inflammation in a humanized transgenic murine model of sickle cell disease.Haematologica · 2024Article
- Inflammation and autoimmunity are interrelated in patients with sickle cell disease at a steady-state condition: implications for vaso-occlusive crisis, pain, and sensory sensitivity.Frontiers in immunology · 2024Article
- Missing the mark(ers): circulating endothelial cells and endothelial-derived extracellular vesicles are elevated in sickle cell disease plasma.Frontiers in immunology · 2024Article
- Hemolysis dictates monocyte differentiation via two distinct pathways in sickle cell disease vaso-occlusion.The Journal of clinical investigation · 2023Article
- Proinflammatory state promotes red blood cell alloimmunization in pediatric patients with sickle cell disease.Blood advances · 2023Article
- Levels of inflammatory markers are differentially expressed in sickle cell anemia and sickle cell trait.EJHaem · 2023Article
- T memory stem cell characteristics in autoimmune diseases and their promising therapeutic values.Frontiers in immunology · 2023Review
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sickle Cell Anemia (SCA) is the most common genetic disorder around the world. The mutation in the β-globin gene is responsible for a higher hemolysis rate, with further involvement of immunological molecules, especially cytokines, chemokines, growth factors, and anaphylatoxins. These molecules are responsible for inducing and attracting immune cells into circulation, thus contributing to increases in leukocytes and other pro-inflammatory mediators, and can culminate in a vaso-occlusive crisis (VOC). This study aimed to characterize the levels of these molecules in SCA patients in different clinical conditions in order to identify potential hallmarks of inflammation in these patients. An analytical prospective study was conducted using the serum of SCA patients in steady-state (StSt;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.