ReviewFrontiers in endocrinology2021
Obesity and Male Reproduction; Placing the Western Diet in Context.
Review in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- The Combination of Nigella sativa Oil-Based Nanoemulsion and Quercetin Alleviates Oxidative Stress From Exogenous Testosterone Through Antioxidant and Anti-Inflammatory Mechanisms in Rats.Veterinary medicine and science · 2026Article
- Obesity Triggers Dysregulation of Essential ABC Transporters in Rat Testis and Sperm.Nutrients · 2026Article
- The association between consumption of ultra-processed foods and sperm quality parameters: a cross-sectional study.BMC research notes · 2025Article
- Diet-induced Obesity: Pathophysiology, Consequences and Target Specific Therapeutic Strategies.Current protein & peptide science · 2025Review
- Effect of Advanced Glycation end Products (AGEs) on Sperm Parameters and Function in C57Bl/6 Mice.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Paternal dietary macronutrient balance and energy intake drive metabolic and behavioral differences among offspring.Nature communications · 2024Article
- Grain versus AIN: Common rodent diets differentially affect health outcomes in adult C57BL/6j mice.PloS one · 2024Article
- Testicular fat deposition attenuates reproductive performance via decreased follicle-stimulating hormone level and sperm meiosis and testosterone synthesis in mouse.Animal bioscience · 2024Article
- Male reproductive traits are differentially affected by dietary macronutrient balance but unrelated to adiposity.Nature communications · 2023Article
- Ketone Body β-Hydroxy-Butyrate Sustains Progressive Motility in Capacitated Human Spermatozoa: A Possible Role in Natural Fertility.Nutrients · 2023Article
- Once a week consumption of Western diet over twelve weeks promotes sustained insulin resistance and non-alcoholic fat liver disease in C57BL/6 J mice.Scientific reports · 2023Article
- Editorial: Molecular mechanisms in diet-mediated inflammatory diseases.Frontiers in nutrition · 2023Article
- The Relationship between Plant-Based Diet Index and Semen Parameters of Men with Infertility: A Cross-Sectional Study.International journal of fertility & sterility · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is mounting evidence that obesity has negative repercussions for reproductive physiology in males. Much of this evidence has accumulated from rodent studies employing diets high in fat and sugar ("high fat" or "western" diets). While excessive fats and carbohydrates have long been considered major determinants of diet induced obesity, a growing body of research suggests that the relationships between diet composition and obesity are more complex than originally thought, involving interactions between dietary macronutrients. However, rodent dietary models have yet to evolve to capture this, instead relying heavily on elevated levels of a single macronutrient. While this approach has highlighted important effects of obesity on male reproduction, it does not allow for interpretation of the complex, interacting effects of dietary protein, carbohydrate and fat. Further, the single nutrient approach limits the ability to draw conclusions about which diets best support reproductive function. Nutritional Geometry offers an alternative approach, assessing outcomes of interest over an extended range of dietary macronutrient compositions. This review explores the practical application of Nutritional Geometry to study the effects of dietary macronutrient balance on male reproduction, including experimental considerations specific to studies of diet and reproductive physiology. Finally, this review discusses the promising use of Nutritional Geometry in the development of evidence-based pre-conception nutritional guidance for men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.