Evidence map›Paper›PMID 33776781›Full record

ArticleFrontiers in pharmacology2021

Ghrelin Inhibits Intestinal Epithelial Cell Apoptosis Through the Unfolded Protein Response Pathway in Ulcerative Colitis.

Lin Zhang, Jian Cheng, Jie Shen, Sheng Wang, Chuanyong Guo, Xiaoming Fan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lin ZhangDepartment of Gastroenterology, Jinshan Hospital, Fudan University, Shanghai, China.
Jian ChengDepartment of Gastroenterology, Jinshan Hospital, Fudan University, Shanghai, China.
Jie ShenCenter of Emergency and Intensive Care Unit, Jinshan Hospital, Fudan University, Shanghai, China.
Sheng WangDepartment of Gastroenterology, Jinshan Hospital, Fudan University and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Chuanyong GuoDepartment of Gastroenterology, Tenth People's Hospital, Tongji University, Shanghai, China.
Xiaoming FanDepartment of Gastroenterology, Jinshan Hospital, Fudan University, Shanghai, China.
Jinshan Hospital of Fudan University · CNShanghai Tenth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) that occurs in the lining of the rectum and colon. Apoptosis of the intestinal epithelial cells (IECs) is common in active UC patients. Ghrelin is reported to be downregulated in apoptosis of IECs induced by tumor necrosis factor-α (TNF-α). Therefore, we hypothesized that ghrelin might play an antiapoptotic role in UC progression, which was investigated using

Indexed as

apoptosisghrelinintestinal epithelial cellulcerative colitisunfolded protein response pathway

Identifiers

PMID33776781
PMCPMC7988211
OpenAlexW3134392632

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.