Evidence map›Paper›PMID 33776741›Full record

ArticleFrontiers in aging neuroscience2021

Exercise and Fitness Neuroprotective Effects: Molecular, Brain Volume and Psychological Correlates and Their Mediating Role in Healthy Late-Middle-Aged Women and Men.

Alba Castells-Sánchez, Francesca Roig-Coll, Rosalia Dacosta-Aguayo, Noemí Lamonja-Vicente, Angelika K Sawicka, Pere Torán-Monserrat, Guillem Pera, Pilar Montero-Alía, Antonio Heras-Tebar, Sira Domènech and 3 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07727577 (Cardiorespiratory Fitness and Acute High-Intensity Exercise Effects on Brain and Cognitive Function in Older Adults), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07727577 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Cardiorespiratory Fitness and Acute High-Intensity Exercise Effects on Brain and Cognitive Function in Older Adults

TypeinterventionalSponsorColby-Sawyer CollegeRan2026 to 2028Enrolled50ConditionsHealthy Aging, Cognitive Benefits, Cardio Respiratory Fitness, Brain ActivityArmsHigh-Intensity Interval Training
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Association between cardiorespiratory fitness and total brain myelin volume among older adults.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Physical activity and the brain myelin content in humans.Frontiers in cellular neuroscience · 2023
    Review
  13. Article
  14. Article
  15. Disentangling Mitochondria in Alzheimer's Disease.International journal of molecular sciences · 2021
    Review
  16. Review
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Alba Castells-SánchezDepartament of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain.
Francesca Roig-CollDepartament of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain.
Rosalia Dacosta-AguayoDepartament of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain.
Noemí Lamonja-VicenteDepartament of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain.
Angelika K SawickaApplied Cognitive Neuroscience Lab, Department of Human Physiology, Medical University of Gdansk, Gdansk, Poland.
Pere Torán-MonserratUnitat de Suport a la Recerca Metropolitana Nord, Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Mataró, Spain.
Guillem PeraUnitat de Suport a la Recerca Metropolitana Nord, Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Mataró, Spain.
Pilar Montero-AlíaUnitat de Suport a la Recerca Metropolitana Nord, Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Mataró, Spain.
Antonio Heras-TebarUnitat de Suport a la Recerca Metropolitana Nord, Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Mataró, Spain.
Sira DomènechInstitut de Diagnòstic per la Imatge, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain.
Marc ViaDepartament of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain.
Kirk I EricksonDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, United States.
Maria MataróDepartament of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain.
Institut Universitari d'Investigació en Atenció Primària Jordi Gol · ESUniversitat de Barcelona · ESHospital Sant Joan de Déu Barcelona · ESGdańsk Medical University · PLHospital Universitari Germans Trias i Pujol · ESUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

brain volumecognitionexercisefitnessmolecular biomarkerspsychological health

Identifiers

PMID33776741
PMCPMC7989549
OpenAlexW3133854972

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.