ArticleFrontiers in human neuroscience2021
Frequency- and Area-Specific Phase Entrainment of Intrinsic Cortical Oscillations by Repetitive Transcranial Magnetic Stimulation.
Article in Frontiers in human neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- A Dose-Finding, Biomarker Validation, and Effectiveness Study of Transcranial Magnetic Stimulation for Adolescents With Depression.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Trial
- Comparing neuromodulation targets to reduce cigarette craving and withdrawal: a randomized clinical trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Trial
- Noninvasive Brain Stimulation Techniques and Their Efficacy in Treating Cognition and Memory in Mild Cognitive Impairment and Alzheimer's Disease-A Systematic Review.Brain sciences · 2026Review
- Differential neural responses to rhythmic and patterned TMS protocols: Insights from EEG spectral analysis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Lightweight EEG Phase Prediction Based on Channel Attention and Spatio-Temporal Parallel Processing.Brain sciences · 2025Article
- Electroencephalographic responses before, during, and after upper limb paired associative stimulation.Data in brief · 2025Article
- A 5-day course of rTMS before pain onset ameliorates future pain and increases sensorimotor peak alpha frequency.bioRxiv : the preprint server for biology · 2024Article
- Interactions of transcranial magnetic stimulation with brain oscillations: a narrative review.Frontiers in systems neuroscience · 2024Review
- Beyond trial-and-error: Individualizing therapeutic transcranial neuromodulation for chronic pain.European journal of pain (London, England) · 2023Review
- Continuous and intermittent theta burst stimulation of primary visual cortex do not modulate resting state functional connectivity: A sham-controlled multi-echo fMRI study.Brain and behavior · 2023Article
- Modulation of cortical beta oscillations influences motor vigor: A rhythmic TMS-EEG study.Human brain mapping · 2023Article
- Frequency modulation of cortical rhythmicity governs behavioral variability, excitability and synchrony of neurons in the visual cortex.Scientific reports · 2022Article
- Entrainment and Spike-Timing Dependent Plasticity - A Review of Proposed Mechanisms of Transcranial Alternating Current Stimulation.Frontiers in systems neuroscience · 2022Review
- Personalized transcranial alternating current stimulation improves sleep quality: Initial findings.Frontiers in human neuroscience · 2022Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synchronous oscillations are ubiquitous throughout the cortex, but the frequency of oscillations differs from area to area. To elucidate the mechanistic architectures underlying various rhythmic activities, we tested whether spontaneous neural oscillations in different local cortical areas and large-scale networks can be phase-entrained by direct perturbation with distinct frequencies of repetitive transcranial magnetic stimulation (rTMS). While recording the electroencephalogram (EEG), we applied single-pulse TMS (sp-TMS) and rTMS at 5, 11, and 23 Hz over the motor or visual cortex. We assessed local and global modulation of phase dynamics using the phase-locking factor (PLF). sp-TMS to the motor and the visual cortex triggered a transient increase in PLF in distinct frequencies that peaked at 21 and 8 Hz, respectively. rTMS at 23 Hz over the motor cortex and 11 Hz over the visual cortex induced a prominent and progressive increase in PLF that lasted for a few cycles after the termination of rTMS. Moreover, the local increase in PLF propagated to other cortical areas. These results suggest that distinct cortical areas have area-specific oscillatory frequencies, and the manipulation of oscillations in local areas impacts other areas through the large-scale oscillatory network with the corresponding frequency specificity. We speculate that rTMS that is close to area-specific frequencies (natural frequencies) enables direct manipulation of brain dynamics and is thus useful for investigating the causal roles of synchronous neural oscillations. Moreover, this technique could be used to treat clinical symptoms associated with impaired oscillations and synchrony.
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