Evidence map›Paper›PMID 33776645›Full record

ArticleFrontiers in neuroscience2021

High-Throughput Functional Characterization of Visceral Afferents by Optical Recordings From Thoracolumbar and Lumbosacral Dorsal Root Ganglia.

Zichao Bian, Tiantian Guo, Shaowei Jiang, Longtu Chen, Jia Liu, Guoan Zheng, Bin Feng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Gut-brain communication: types of sensory nerves and mechanisms of activation.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  4. Review
  5. Article
  6. Sex differences in zymosan-induced behavioral visceral hypersensitivity and colorectal afferent sensitization.American journal of physiology. Gastrointestinal and liver physiology · 2024
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zichao BianDepartment of Biomedical Engineering, University of Connecticut, Mansfield, CT, United States.
Tiantian GuoDepartment of Biomedical Engineering, University of Connecticut, Mansfield, CT, United States.
Shaowei JiangDepartment of Biomedical Engineering, University of Connecticut, Mansfield, CT, United States.
Longtu ChenDepartment of Biomedical Engineering, University of Connecticut, Mansfield, CT, United States.
Jia LiuDepartment of Biomedical Engineering, University of Connecticut, Mansfield, CT, United States.
Guoan ZhengDepartment of Biomedical Engineering, University of Connecticut, Mansfield, CT, United States.
Bin FengDepartment of Biomedical Engineering, University of Connecticut, Mansfield, CT, United States.
University of Connecticut · US

Funding

Determining the topology and molecular profiles of nociceptive DRG neurons innervating distal colon and rectumU01NS113873 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI FENG, BIN · 2019 to 2021
$2.0M
The Role of Lumbar Splanchnic Innervations in Visceral Nociception and PainR01DK120824 · NIDDK · UNIVERSITY OF CONNECTICUT STORRS · PI FENG, BIN · 2019 to 2023
$2.0M
Mechanisms of DRG Stimulation to Modulate Visceral Afferent FunctionR03DK114546 · NIDDK · UNIVERSITY OF CONNECTICUT STORRS · PI FENG, BIN · 2018 to 2019
$160k
NIDDK NIH HHS R01 DK120824NIDDK NIH HHS R03 DK114546NINDS NIH HHS U01 NS113873
6 · The paper itself

Abstract

Functional understanding of visceral afferents is important for developing the new treatment to visceral hypersensitivity and pain. The sparse distribution of visceral afferents in dorsal root ganglia (DRGs) has challenged conventional electrophysiological recordings. Alternatively, Ca

Indexed as

colorectal distensiondorsal root gangliaGCaMPlumbar splanchnicoptical recordingpelvicvisceralvisceral afferent

Identifiers

PMID33776645
PMCPMC7991386
OpenAlexW3135545485

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.