ReviewFrontiers in neuroscience2021
Neuropeptides as Primary Mediators of Brain Circuit Connectivity.
Review in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 44 citations in OpenAlex.
- Balancing acts: lateral hypothalamic circuits coordinating feeding, anxiety, and social interactions.Reviews in endocrine & metabolic disorders · 2026Review
- FLP-15 functions through the GPCR NPR-3 to regulate local and global search behaviours in Caenorhabditis elegans.Communications biology · 2026Article
- Hypertension and brain damage: evidence from rodent models.Laboratory animal research · 2026Review
- Neuropeptides in control of left-right neural circuits.Trends in neurosciences · 2026Review
- IGF-like growth factors that couple food sensing to developmental decisions employ different release mechanisms in a single pair ofbioRxiv : the preprint server for biology · 2026Article
- Spatially Mapping Neuropeptide Isomers via MALDI Trapped Ion Mobility MS Imaging.Analytical chemistry · 2025Article
- Gastrin-releasing peptide signaling in the nucleus accumbens medial shell regulates neuronal excitability and motivation.Nature communications · 2025Article
- Orexin and Lifestyle Habits: A Meaningful Connection Among Nutrition, Physical Activity, and Sleep Pattern in Health and Diseases.International journal of molecular sciences · 2025Review
- Neuropeptide-mediated synaptic plasticity regulates context-dependent mating behaviors in Drosophila.PLoS biology · 2025Article
- Expanding our understanding of (mal)adapted stress physiology in psychiatric disorders: achieving single-cell characterisation of steroids and neuropeptides.Neurobiology of stress · 2025Review
- Mapping and decoding neuropeptide signaling networks in nervous system function.Current opinion in neurobiology · 2025Review
- Volumetric mesoscopic electrophysiology: a new imaging modality for the nonhuman primate.Journal of neurophysiology · 2025Article
- Computational approaches for identifying neuropeptides: A comprehensive review.Molecular therapy. Nucleic acids · 2025Review
- Neuropeptides: The Evergreen Jack-of-All-Trades in Neuronal Circuit Development and Regulation.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Adaptive robustness through incoherent signaling mechanisms in a regenerative brain.Cell reports · 2024Article
- Lineage-tracing reveals an expanded population of NPY neurons in the inferior colliculus.Journal of neurophysiology · 2024Article
- Lineage-tracing reveals an expanded population of NPY neurons in the inferior colliculus.bioRxiv : the preprint server for biology · 2024Article
- Neuronal diversity of neuropeptide signaling, including galanin, in the mouse locus coeruleus.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Understanding Neuropeptide Transmission in the Brain by Optical Uncaging and Release.ACS chemical neuroscience · 2023Review
- A resveratrol derivative modulates TRH and TRH-like peptide expression throughout the brain and peripheral tissues of male rats.Endocrinology, diabetes & metabolism · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Across sleep and wakefulness, brain function requires inter-neuronal interactions lasting beyond seconds. Yet, most studies of neural circuit connectivity focus on millisecond-scale interactions mediated by the classic fast transmitters, GABA and glutamate. In contrast, neural circuit roles of the largest transmitter family in the brain-the slow-acting peptide transmitters-remain relatively overlooked, or described as "modulatory." Neuropeptides may efficiently implement sustained neural circuit connectivity, since they are not rapidly removed from the extracellular space, and their prolonged action does not require continuous presynaptic firing. From this perspective, we review actions of evolutionarily-conserved neuropeptides made by brain-wide-projecting hypothalamic neurons, focusing on lateral hypothalamus (LH) neuropeptides essential for stable consciousness: the orexins/hypocretins. Action potential-dependent orexin release inside and outside the hypothalamus evokes slow postsynaptic excitation. This excitation does not arise from modulation of classic neurotransmission, but involves direct action of orexins on their specific G-protein coupled receptors (GPCRs) coupled to ion channels. While millisecond-scale, GABA/glutamate connectivity within the LH may not be strong, re-assessing LH microcircuits from the peptidergic viewpoint is consistent with slow local microcircuits. The sustained actions of neuropeptides on neuronal membrane potential may enable core brain functions, such as temporal integration and the creation of lasting permissive signals that act as "eligibility traces" for context-dependent information routing and plasticity. The slowness of neuropeptides has unique advantages for efficient neuronal processing and feedback control of consciousness.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.