Evidence map›Paper›PMID 33776567›Full record

ArticleJournal of medical biochemistry2021

Association of salivary steroid hormones and their ratios with time-domain heart rate variability indices in healthy individuals.

Eglė Mazgelytė, Gintaras Chomentauskas, Edita Dereškevičiūtė, Virginija Rekienė, Audronė Jakaitienė, Tomas Petrėnas, Jurgita Songailienė, Algirdas Utkus, Kučinskienė Zita Aušrelė, Dovilė Karčiauskaitė

Open access · diamondAbstract read
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In one paragraph

Article in Journal of medical biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Eglė MazgelytėVilnius University, Faculty of Medicine, Institute of Biomedical Sciences, Department of Physiology, Biochemistry, Microbiology, and Laboratory Medicine, Vilnius, Lithuania.
Gintaras ChomentauskasHuman Study Center, Vilnius, Lithuania.
Edita DereškevičiūtėHuman Study Center, Vilnius, Lithuania.
Virginija RekienėHuman Study Center, Vilnius, Lithuania.
Audronė JakaitienėVilnius University, Faculty of Medicine, Institute of Biomedical Sciences, Department of Human and Medical Genetics, Vilnius, Lithuania.
Tomas PetrėnasVilnius University, Faculty of Medicine, Institute of Biomedical Sciences, Department of Human and Medical Genetics, Vilnius, Lithuania.
Jurgita SongailienėVilnius University, Faculty of Medicine, Institute of Biomedical Sciences, Department of Human and Medical Genetics, Vilnius, Lithuania.
Algirdas UtkusVilnius University, Faculty of Medicine, Institute of Biomedical Sciences, Department of Human and Medical Genetics, Vilnius, Lithuania.
Kučinskienė Zita AušrelėVilnius University, Faculty of Medicine, Institute of Biomedical Sciences, Department of Physiology, Biochemistry, Microbiology, and Laboratory Medicine, Vilnius, Lithuania.
Dovilė KarčiauskaitėVilnius University, Faculty of Medicine, Institute of Biomedical Sciences, Department of Physiology, Biochemistry, Microbiology, and Laboratory Medicine, Vilnius, Lithuania.
Lithuanian Social Research Centre · LT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStress system consists of the hypothalamicpituitary-adrenal (HPA) axis and the locus caeruleus/norepinephrine-autonomic nervous system (ANS). Traditionally, HPA axis activity is evaluated by measuring its end-product cortisol, while the activity of ANS is assessed using heart rate variability (HRV) indices. Alterations in cortisol levels and HRV measures during laboratory-based stress tasks were extensively studied in previous research. However, scarce data exist on the associations of HRV measures with the levels of other adrenal steroid hormones under baseline conditions. Thus, we aimed to evaluate the activity of the HPA axis by measuring salivary cortisol, cortisone, dehydroepiandrosterone (DHEA) levels, and their ratios and to examine its association with HRV measures in a sample of healthy young and middle-aged adults.

methodsFor each participant (n=40), three data collection sessions taking place at the same time of the day were scheduled within five working days. Participants completed a self-reported questionnaire on sociodemographic and lifestyle characteristics, filled out t h e Perceived Stress Scale and State-Trait Anxiety Inventory. Also, saliva samples were collected, and physiological measures, including resting HR and HRV, were recorded during three data collection sessions.

resultsStatistically significant associations between diminished parasympathetic vagal tone evaluated by time domain HRV measures and higher salivary cortisol, lower DHEA levels, as well as decreased DHEA to cortisol ratio, were found. Also, physiological stress indicators (i.e., HRV) showed greater intraindividual stability compared with biochemical biomarkers (i.e., salivary steroid hormones) within five days.

conclusionsOur findings suggest that both cortisol and DHEA mediate the link between two stress-sensitive homeostatic systems.

Indexed as

autonomic nervous systemheart rate variabilityhypothalamic-pituitary-adrenal axissteroid hormonesstress biomarkers

Identifiers

PMID33776567
PMCPMC7982294
OpenAlexW3045011256

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.