Evidence map›Paper›PMID 33776373›Full record

ArticleWorld journal of gastroenterology2021

Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis.

José Carlos Rodrigues Nascimento, Lianna C Pereira, Juliana Magalhães C Rêgo, Ronaldo P Dias, Paulo Goberlânio B Silva, Silvio Alencar C Sobrinho, Gustavo R Coelho, Ivelise Regina C Brasil, Edmilson F Oliveira-Filho, James S Owen and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Apolipoprotein E and viral infection: Risks and Mechanisms.Molecular therapy. Nucleic acids · 2023
    Review
  3. Article
  4. Apolipoproteins: New players in cancers.Frontiers in pharmacology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

José Carlos Rodrigues NascimentoDepartment of Anesthesia and Surgery Liver Transplantation, Fortaleza General Hospital, Fortaleza 60150-160, CE, Brazil.
Lianna C PereiraLaboratory of the Biology of Tissue Healing, Ontogeny and Nutrition, Department of Morphology and Institute of Biomedicine, School of Medicine, Federal University of Ceará, Fortaleza 60430-270, CE, Brazil.
Juliana Magalhães C RêgoLaboratory of the Biology of Tissue Healing, Ontogeny and Nutrition, Department of Morphology and Institute of Biomedicine, School of Medicine, Federal University of Ceará, Fortaleza 60430-270, CE, Brazil.
Ronaldo P DiasLaboratory of the Biology of Tissue Healing, Ontogeny and Nutrition, Department of Morphology and Institute of Biomedicine, School of Medicine, Federal University of Ceará, Fortaleza 60430-270, CE, Brazil.
Paulo Goberlânio B SilvaDepartment of Dental Clinic, Federal University of Ceará, Fortaleza 60430-270, CE, Brazil.
Silvio Alencar C SobrinhoLaboratory of the Biology of Tissue Healing, Ontogeny and Nutrition, Department of Morphology and Institute of Biomedicine, School of Medicine, Federal University of Ceará, Fortaleza 60430-270, CE, Brazil.
Gustavo R CoelhoDepartment of Surgery, Liver Transplant Unit of Federal University of Ceará, Fortaleza 60430-270, CE, Brazil.
Ivelise Regina C BrasilTransplantation Division, Hospital Geral de Fortaleza, Fortaleza 60175-742, CE, Brazil.
Edmilson F Oliveira-FilhoInstitute of Virology, Charité Universitätsmedizin Berlin, Berlin 10117, Germany.
James S OwenUCL Medical School, Royal Free Campus, London NW3 2PF, United Kingdom.
Pierluigi ToniuttoDepartment of Specialized Medicine, Hepatology Liver Transplantation Unit, Azienda Sanitaria Universitaria Integrata of Udine, Udine I-33100, Italy.
Reinaldo B OriáLaboratory of the Biology of Tissue Healing, Ontogeny and Nutrition, Department of Morphology and Institute of Biomedicine, School of Medicine, Federal University of Ceará, Fortaleza 60430-270, CE, Brazil. oria@ufc.br.
Universidade Federal do Ceará · BRHospital Geral de Fortaleza · BRBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DEOspedale Santa Maria della Misericordia di Udine · ITThe Royal Free Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatitis C virus (HCV) infection is responsible for a chronic liver inflammation, which may cause end-stage liver disease and hepatocellular carcinoma. Apolipoprotein E (protein: ApoE, gene:

aimTo determine whether

methodsThis was a cohort study in which 179 patients, both genders and aged 34-70 years, were included before or after (up to 10 years follow-up) OLT. Liver injury severity was assessed using different criteria, including METAVIR and models for end-stage liver disease.

resultsThe

conclusionOur results suggest that the E4 allele protects against progression of liver fibrosis and degree of inflammation in HCV-infected patients.

Indexed as

Hepatitis CLiver NeoplasmsLiver TransplantationAdultAgedApolipoproteins ECohort StudiesFemaleHepacivirusHumansLiver CirrhosisMaleMiddle AgedNeoplasm Recurrence, LocalRecurrenceApolipoproteins EApolipoprotein EHepatitis C virusHepatocellular carcinomaLiver cirrhosisLiver transplantationPolymorphism

Identifiers

PMID33776373
PMCPMC7985730
OpenAlexW3137880854

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.