ReviewVeterinary world2021
Neurobiology of anesthetic-surgical stress and induced behavioral changes in dogs and cats: A review.
Review in Veterinary world, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 57 citations in OpenAlex.
- Effects of pregabalin added to a multimodal anesthetic protocol in cats undergoing ovariohysterectomy.Frontiers in veterinary science · 2026Trial
- Stress, needs, and behaviour: understanding chronic stress in pet domestic dogs (Canis lupus familiaris) from the prism of needs.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Ultrasound-Guided Thoracic Paravertebral, Erector Spinae Plane and Quadratus Lumborum Blocks During Emergency Laparotomy in Dogs: A Multicenter Retrospective Study.Veterinary sciences · 2026Article
- Comparative Evaluation of Oxidative Stress, Cortisol, Inflammatory Response, and Systemic COAntioxidants (Basel, Switzerland) · 2026Article
- Assessment of Maropitant Citrate Effectiveness as an Intraoperative Analgesic Through Monitoring Parasympathetic Tone Activity in Female Dogs Undergoing Ovariohysterectomy.Veterinary sciences · 2026Article
- Impact of combined unilateral mastectomy and ovariohysterectomy on acute phase response and wound healing in dogs with mammary gland tumors.BMC veterinary research · 2026Article
- Influence of Circadian Rhythm on the Surgical Stress Response in Bitches Undergoing Elective Ovariohysterectomy.Animals : an open access journal from MDPI · 2026Article
- Evaluation of the Cardiovascular and Serotonergic Modulatory Effects of Ondansetron in Healthy Dogs Under Anesthesia.Veterinary sciences · 2026Article
- The Impact of Etomidate on Tear Secretion and Oxidative Stress Markers in Domestic Male Cats: A Clinical Study.Veterinary medicine international · 2026Article
- Comparison of the Anxiolytic and Analgesic Effects of Gabapentin and Pregabalin in Cats: A Systematic Review.Animals : an open access journal from MDPI · 2025Article
- Effects of adding atracurium to Lidocaine solution during intravenous regional anesthesia in dogs.Irish veterinary journal · 2025Article
- Efficacy and sterilization resilience of silicone rubber bands as an alternative to suture ligation in feline orchiectomy.Veterinary world · 2025Article
- Assessing Facial Thermal Nociceptive Response in Female Dogs After Elective Ovariohysterectomy Anesthetized with Isoflurane and Treated with Cannabidiol and Meloxicam Analgesia.Animals : an open access journal from MDPI · 2025Article
- The neurobiological basis of emotions and their connection to facial expressions in non-human mammals: insights in nonverbal communication.Frontiers in veterinary science · 2025Review
- Detection of maladaptive pain in dogs referred for behavioral complaints: challenges and opportunities.Frontiers in behavioral neuroscience · 2025Article
- Assessment of acute and chronic pain in canine internal medicine-what is missing in our diagnostic toolbox?Frontiers in veterinary science · 2025Article
- Impact of Ovarian Suspensory Ligament Rupture on Surgical Stress in Elective Ovariohysterectomy in Bitches.Veterinary sciences · 2024Article
- In Vivo Evaluation of Demineralized Bone Matrix with Cancellous Bone Putty Formed Using Hydroxyethyl Cellulose as an Allograft Material in a Canine Tibial Defect Model.Animals : an open access journal from MDPI · 2024Article
- Use of CaudalAnimals : an open access journal from MDPI · 2024Article
- Use of Gabapentin or Alprazolam in Cats during Postoperative, Short-Term Hospitalization.Animals : an open access journal from MDPI · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The anesthetic-surgical stress response consists of metabolic, neuroendocrine, hemodynamic, immunological, and behavioral adaptations through chemical mediators such as the adrenocorticotropic hormone, growth hormone, antidiuretic hormone, cortisol, aldosterone, angiotensin II, thyroid-stimulating hormone, thyroxine, triiodothyronine, follicle-stimulating hormone, luteinizing hormone, catecholamines, insulin, interleukin (IL)-1, IL-6, tumor necrosis factor-alpha, and prostaglandin E-2. Behavioral changes include adopting the so-called prayer posture, altered facial expressions, hyporexia or anorexia, drowsiness, sleep disorders, restriction of movement, licking or biting the injured area, and vocalizations. Overall, these changes are essential mechanisms to counteract harmful stimuli. However, if uncontrolled surgical stress persists, recovery time may be prolonged, along with increased susceptibility to infections in the post-operative period. This review discusses the neurobiology and most relevant organic responses to pain and anesthetic-surgical stress in dogs and cats. It highlights the role of stress biomarkers and their influence on autonomous and demeanor aspects and emphasizes the importance of understanding and correlating all factors to provide a more accurate assessment of pain and animal welfare in dogs and cats throughout the surgical process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.