ArticleJournal of aerosol science2021
Inter-species Variabilities of Droplet Transport, Size Change, and Deposition in Human and Rat Respiratory Systems: An
Article in Journal of aerosol science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 14 citations in OpenAlex.
- Computational fluid particle dynamics modeling of tangential flow filtration in perfusion cell culture.Bioprocess and biosystems engineering · 2025Article
- A Critical Analysis of the CFD-DEM Simulation of Pharmaceutical Aerosols Deposition in Upper Intra-Thoracic Airways: Considerations on Aerosol Transport and Deposition.Pharmaceutics · 2024Article
- Designing Aerosol Therapies Based on the Integrated Evaluation of In Vitro, In Vivo, and In Silico Data.Pharmaceutics · 2023Article
- Prediction of transport, deposition, and resultant immune response of nasal spray vaccine droplets using a CFPD-HCD model in a 6-year-old upper airway geometry to potentially prevent COVID-19.Experimental and computational multiphase flow · 2023Article
- How severe acute respiratory syndrome coronavirus-2 aerosol propagates through the age-specific upper airways.Physics of fluids (Woodbury, N.Y. : 1994) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
To speculate on human responses from animal studies, scale-up factors (body weight, lung volume, or lung surface area ratios) are currently used to extrapolate aerosol lung deposition from animal to human. However, those existing scale-up methods between animals and humans neglected two important inter-subject variability factors: (1) the effect of anatomical differences in respiratory systems from mouth/nose to peripheral lungs between human and rat, and (2) the effect of spatial distributions and temporal evolutions of temperature and relative humidity (RH) on droplet size change dynamics between the two species. To test the above-mentioned inter-species variability effects on droplet fates in pulmonary routes and generate correlations as a precise scale-up method for lung deposition estimation, this study simulated the transport of pure-water droplets in both human and Sprague-Dawley (SD) rat respiratory systems. Employing an experimentally validated Euler-Lagrange based Computational Fluid-Particle Dynamics (CFPD) model, simulations were performed for droplets with Stk/Fr between 8.36×10
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.