ArticleIndian journal of anaesthesia2021
Effect of hand-holding and conversation alone or with midazolam premedication on preoperative anxiety in adult patients-A randomised controlled trial.
Article in Indian journal of anaesthesia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06742814 (Effects of Stress Ball Use for Patients Undergoing Local Anesthesia in Ambulatory Surgery), which is not on this map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Stress Ball Use for Patients Undergoing Local Anesthesia in Ambulatory Surgery
Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Effects of music and conversation on pain and anxiety levels during transrectal ultrasound-guided prostate biopsy: a randomized-controlled prospective study.Sao Paulo medical journal = Revista paulista de medicina · 2025Trial
- Article
- Nurse-led Enhanced Recovery after Surgery Programs: Potential Solution to Shorten Postoperative Recovery.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- Effect of binaural beat music and noise cancelling headphones on intraoperative anxiety in patients undergoing spinal anaesthesia - A randomised controlled study.Indian journal of anaesthesia · 2023Article
- I wanna hold your hand: Handholding is preferred over gentle stroking for emotion regulation.PloS one · 2023Article
- The battle against perioperative glycaemic control: Hard to win?Indian journal of anaesthesia · 2022Article
- Effect of pre-operative communication using anaesthesia information sheet on pre-operative anxiety of patients undergoing elective surgery-A randomised controlled study.Indian journal of anaesthesia · 2022Article
- Use of a non-invasive biomarker salivary alpha-amylase to assess the role of probiotics in sleep regulation and stress attenuation in surgical patients: A randomised double-blind clinical trial.Indian journal of anaesthesia · 2021Article
- Enhanced recovery after surgery (ERAS)…. still a distant speck on the horizon !Indian journal of anaesthesia · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsAnxiety causing stress is most profound before surgery. Anxiolytics are used routinely to combat perioperative anxiety. Studies have shown that hand-holding and communication are useful in reducing anxiety levels intraoperatively. This study compares the effectiveness of the same with pharmacological interventions in allaying preoperative anxiety. MATERIAL AND
methodsThis is a three-arm parallel-group randomised controlled trial. A total of 90 adult patients aged <45 years and of American Society of Anesthesiologists (ASA) grade 1-2, undergoing laparoscopic surgery were enroled in this study. Patients received either intravenous (IV) midazolam (group M) or hand-holding and conversation (group HC), or a combination of IV midazolam and holding and conversation (group HCM) in the preoperative room. Anxiety, heart rate (HR) and mean blood pressure (MBP) were recorded before and 20 minutes after the intervention. Anxiety was measured using the Amsterdam preoperative anxiety and information scale. The analysis of covariance (ANCOVA) test was done to analyse the difference between the groups.
resultsThe mean anxiety scores were significantly different in the three groups (p = 0.04) after intervention, with the lowest score in group HCM, followed by group HC and the highest score in group M. The mean heart rates were also significantly different in the three groups after intervention but MBP was not significantly different in the three groups.
conclusionA combination of hand-holding and conversation and midazolam is best for allaying preoperative anxiety in patients undergoing laparoscopic surgeries than either method alone.
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