Evidence map›Paper›PMID 33776068›Full record

ArticleExperimental mechanics2021

Arterial Wall Stiffening in Caveolin-1 Deficiency-Induced Pulmonary Artery Hypertension in Mice.

J Moreno, D Escobedo, C Calhoun, C Jourdan Le Saux, H C Han

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental mechanics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Genes · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

J MorenoDepartment of Mechanical Engineering, University of Texas at San Antonio.
D EscobedoDepartment of Medicine/Cardiology, University of Texas Health Science Center at San Antonio, San Antonio, TX.
C CalhounDepartment of Medicine/Cardiology, University of Texas Health Science Center at San Antonio, San Antonio, TX.
C Jourdan Le SauxDepartment of Medicine/Cardiology, University of Texas Health Science Center at San Antonio, San Antonio, TX.
H C HanDepartment of Mechanical Engineering, University of Texas at San Antonio.
The University of Texas Health Science Center at San Antonio · US

Funding

Biomechanical Mechanisms of Artery TortuosityR01HL095852 · NHLBI · UNIVERSITY OF TEXAS SAN ANTONIO · PI HAN, HAI-CHAO · 2010 to 2014
$1.8M
Characterization of the Various Senescent Cells in the Aging LungsR21AG052744 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LE SAUX, CLAUDE · 2016 to 2017
$436k
NHLBI NIH HHS HHSN268201000036CNHLBI NIH HHS R01 HL095852NIA NIH HHS R21 AG052744
6 · The paper itself

Abstract

backgroundPulmonary artery hypertension (PAH) is a complex disorder that can lead to right heart failure. The generation of caveolin-1 deficient mice (CAV-1

objectiveTo determine the histological and functional changes in the pulmonary and carotid arteries in CAV-1

methodsPulmonary and carotid arteries of young (4-6 months old) and mature (9-12 months old) CAV-1

resultsArtery stiffness increases in CAV-1

conclusionsWe demonstrated that an increase in artery stiffness is associated with CAV-1 deficiency-induced pulmonary hypertension. These results improve our understanding of artery remodeling in PAH.

Indexed as

arteriescaveolin-1 deficiencymechanical stiffnessmicePulmonary hypertension

Identifiers

PMID33776068
PMCPMC7993546
OpenAlexW3093090832

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.