Evidence map›Paper›PMID 33776061›Full record

ArticleAIChE journal. American Institute of Chemical Engineers2021

Structural insights into peptide self-assembly using photo-induced crosslinking experiments and discontinuous molecular dynamics.

Samuel J Bunce, Yiming Wang, Sheena E Radford, Andrew J Wilson, Carol K Hall

Abstract read
In one paragraph

Article in AIChE journal. American Institute of Chemical Engineers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Peptide Self-Assembled Nanocarriers for Cancer Drug Delivery.The journal of physical chemistry. B · 2023
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Samuel J BunceSchool of Chemistry University of Leeds Leeds UK.
Yiming WangDepartment of Chemical and Biomolecular Engineering North Carolina State University Raleigh North Carolina USA.ORCID https://orcid.org/0000-0003-3657-6100
Sheena E RadfordAstbury Centre for Structural Molecular Biology University of Leeds Leeds UK.
Andrew J WilsonSchool of Chemistry University of Leeds Leeds UK.ORCID https://orcid.org/0000-0001-9852-6366
Carol K HallDepartment of Chemical and Biomolecular Engineering North Carolina State University Raleigh North Carolina USA.

Funding

Biotechnology and Biological Sciences Research Council BB/J014443/1Wellcome Trust
6 · The paper itself

Abstract

Determining the structure of the (oligomeric) intermediates that form during the self-assembly of amyloidogenic peptides is challenging because of their heterogeneous and dynamic nature. Thus, there is need for methodology to analyze the underlying molecular structure of these transient species. In this work, a combination of fluorescence quenching, photo-induced crosslinking (PIC) and molecular dynamics simulation was used to study the assembly of a synthetic amyloid-forming peptide, Aβ

Indexed as

amyloid‐forming peptidediscontinuous molecular dynamicspeptide self assemblyphoto‐induced crosslinking

Identifiers

PMID33776061
PMCPMC7988534

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.