Evidence map›Paper›PMID 33776010›Full record

ArticleInternal medicine (Tokyo, Japan)2021

Atezolizumab-associated Dermatomyositis in Advanced Small-cell Lung Carcinoma.

Yoshitaka Yamaguchi, Mari Aso, Hikaru Nagasawa, Manabu Wada

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Drug eruptions with novel targeted therapies - immune checkpoint and EGFR inhibitors.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yoshitaka YamaguchiDepartment of Neurology, Yamagata Prefectural Central Hospital, Japan.
Mari AsoDepartment of Respiratory Medicine, Yamagata Prefectural Central Hospital, Japan.
Hikaru NagasawaDepartment of Neurology, Yamagata Prefectural Central Hospital, Japan.
Manabu WadaDepartment of Neurology, Yamagata Prefectural Central Hospital, Japan.
Yamagata Prefectural Central Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dermatomyositis is a rare immune-related adverse event caused by immune checkpoint inhibitors. We herein report a 75-year-old Japanese man with small-cell lung carcinoma who developed dermatomyositis after the administration of atezolizumab. He developed rashes on day 13 and myalgia and motor weakness on day 30 of the first administration of atezolizumab. Anti-transcriptional intermediary factor 1-gamma antibody was positive, and serum interleukin-6 levels were prominently elevated in the acute phase. Symptoms were improved by corticosteroid therapy. This is the first report of dermatomyositis associated with atezolizumab. Clinicians should be aware of the possibility of dermatomyositis after the administration of immune checkpoint inhibitors.

Indexed as

CarcinomaDermatomyositisLung NeoplasmsAgedAntibodies, Monoclonal, HumanizedHumansLungMaleAntibodies, Monoclonal, Humanizedatezolizumabanti-transcriptional intermediary factor 1-gammma antibodyatezolizumabdermatomyositisimmune checkpoint inhibitorimmune-related adverse eventinterleukin-6

Identifiers

PMID33776010
PMCPMC8502675
OpenAlexW3149951933

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.