Trial reportEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology2021
Proximal optimisation technique versus final kissing balloon inflation in coronary bifurcation lesions: the randomised, multicentre PROPOT trial.
Trial report in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Imaging Comparisons Between Bifurcation Stenting Procedures Performed in Human Patients and Those Within Reanimated Swine Hearts.JACC. Advances · 2026Article
- Postdilation Strategies Following Provisional Stenting of Left Main Coronary Bifurcations: Insights From Patient-Specific Computational Simulations.JACC. Advances · 2026Article
- Dual-balloon overlapping post-dilation for stent optimization in markedly dilated coronary artery.Frontiers in cardiovascular medicine · 2026Article
- Role of Final Kissing Balloon Inflation in Left Main Distal Bifurcation Single Stenting: Insights from Angiographic Microvascular Resistance.Medicina (Kaunas, Lithuania) · 2025Article
- Coronary Bifurcation PCI-Part I: Fundamentals.Journal of cardiovascular development and disease · 2025Review
- Assessment of fractal ratio of vessel diameters in coronary bifurcation lesions by angiography and intravascular ultrasound.Cardiovascular intervention and therapeutics · 2025Article
- State-of-the-art percutaneous coronary intervention for left main coronary artery disease in Japan.Cardiovascular intervention and therapeutics · 2024Review
- Current Challenges in Coronary Bifurcation Interventions.Medicina (Kaunas, Lithuania) · 2024Review
- Impact of Medina classification on clinical outcomes of imaging-guided coronary bifurcation stenting.International journal of cardiology. Heart & vasculature · 2023Article
- Impact of coronary bifurcation angle on stent malapposition in a randomized comparison between proximal optimization technique followed by side branch dilatation and kissing balloon inflation.International journal of cardiology. Heart & vasculature · 2023Article
- Vascular healing after kissing balloon inflation: Nine-month 3D optical coherence tomography analysis in corelab.International journal of cardiology. Heart & vasculature · 2022Article
- A novel technique of proximal optimization with kissing balloon inflation in bifurcation lesions.Cardiology journal · 2022Article
- Post-stenting optimisation techniques in bifurcation percutaneous coronary interventions: much remains to be explored.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2021Article
- Standardisation of techniques for bifurcation stenting optimisation: the journey continues.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2021Article
- Reply: When is the optimal time point for detecting malapposition in coronary bifurcation trials?EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2021Article
- Letter: When is the optimal time point for detecting malapposition in coronary bifurcation trials?EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2021Article
- Observational
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21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClinical implications of the proximal optimisation technique (POT) for bifurcation lesions have not been investigated in a randomised controlled trial.
aimsThis study aimed to investigate whether POT is superior in terms of stent apposition compared with the conventional kissing balloon technique (KBT) in real-life bifurcation lesions using optical coherence tomography (OCT).
methodsA total of 120 patients from 15 centres were randomised into two groups - POT followed by side branch dilation or KBT. Finally, 57 and 58 patients in the POT and KBT groups, respectively, were analysed. OCT was performed at baseline, immediately after wire recrossing to the side branch, and at the final procedure.
resultsThe primary endpoint was the rate of malapposed struts assessed by the final OCT. The rate of malapposed struts did not differ between the POT and KBT groups (in-stent proximal site: 10.4% vs 7.7%, p=0.33; bifurcation core: 1.4% vs 1.1%, p=0.67; core's distal edge: 6.2% vs 5.3%, p=0.59). More additional treatments were required among the POT group (40.4% vs 6.9%, p<0.01). At one-year follow-up, only one patient in each group underwent target lesion revascularisation (2.0% vs 1.9%).
conclusionsPOT followed by side branch dilation did not show any advantages over conventional KBT in terms of stent apposition; however, excellent midterm clinical outcomes were observed in both strategies.
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