ArticleInternational journal of radiation oncology, biology, physics2021
Oxygen-Sensitive MRI: A Predictive Imaging Biomarker for Tumor Radiation Response?
Article in International journal of radiation oncology, biology, physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- Phase-Sensitive Modeling Improves Fat DESPOT Multiparametric Relaxation Mapping in Fat-Water Mixtures.Magnetic resonance in medicine · 2026Article
- Whole-Body Oxygen-Enhanced MRI of Tumor-Bearing Mice Under Hyperbaric Oxygenation.Magnetic resonance in medicine · 2026Article
- Combining Oxygen-Enhanced MRI and Electron Paramagnetic Resonance Oximetry for Quantitative OE-MRI (qOE-MRI) as a Method for Mapping Absolute Oxygen Levels (pOMagnetic resonance in medicine · 2026Article
- Spatiotemporal Mapping of Tumor Microenvironment Remodeling During Fiber-Optic Photothermal Therapy: A Multiparametric MRI Study in 4T1 Breast Cancer Xenografts.Chemical & biomedical imaging · 2026Article
- MRI for biology-guided radiation therapy: Are we there yet? A summary of the 2024 ISMRM member-initiated session.Magnetic resonance in medicine · 2025Review
- Quantification of Oxygenation and Oxygen Consumption Rates in the Mouse Brain Based on Tissue Oxygen Level-Dependent (TOLD) MRI.NMR in biomedicine · 2025Article
- Magnetic Resonance Imaging Techniques for Post-Treatment Evaluation After External Beam Radiation Therapy of Prostate Cancer: Narrative Review.Clinics and practice · 2024Review
- Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024Article
- Tumor Hypoxia: Long Ignored but Now Detectable and Potentially Actionable.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024Article
- Current status of optoacoustic breast imaging and future trends in clinical application: is it ready for prime time?European radiology · 2024Review
- Evaluations of an Early Change in Tumor Pathophysiology in Response to Radiotherapy with Oxygen Enhanced Electron Paramagnetic Resonance Imaging (OE EPRI).Molecular imaging and biology · 2024Article
- Biomarker-driven molecular imaging probes in radiotherapy.Theranostics · 2024Review
- Hyperoxic BOLD-MRI-Based Characterization of Breast Cancer Molecular Subtypes Is Independent of the Supplied Amount of Oxygen: A Preclinical Study.Diagnostics (Basel, Switzerland) · 2023Article
- Dynamic 2-deoxy-D-glucose-enhanced multispectral optoacoustic tomography for assessing metabolism and vascular hemodynamics of breast cancer.Photoacoustics · 2023Article
- Dodecafluoropentane Emulsion as a Radiosensitizer in Glioblastoma Multiforme.Cancer research communications · 2023Article
- TThe British journal of radiology · 2023Article
- The MANGO study: a prospective investigation of oxygen enhanced and blood-oxygen level dependent MRI as imaging biomarkers of hypoxia in glioblastoma.Frontiers in oncology · 2023Article
- The future of MRI in radiation therapy: Challenges and opportunities for the MR community.Magnetic resonance in medicine · 2022Review
- Noninvasive optoacoustic microangiography reveals dose and size dependency of radiation-induced deep tumor vasculature remodeling.Neoplasia (New York, N.Y.) · 2022Article
- The Potential of Photoacoustic Imaging in Radiation Oncology.Frontiers in oncology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeTo develop a noninvasive prognostic imaging biomarker related to hypoxia to predict SABR tumor control. METHODS AND MATERIALS: A total of 145 subcutaneous syngeneic Dunning prostate R3327-AT1 rat tumors were focally irradiated once using cone beam computed tomography guidance on a small animal irradiator at 225 kV. Various doses in the range of 0 to 100 Gy were administered, while rats breathed air or oxygen, and tumor control was assessed up to 200 days. Oxygen-sensitive magnetic resonance imaging (MRI) (T
resultsIncreasing radiation dose in the range of 0 to 90 Gy enhanced tumor control of air-breathing rats with a TCD
conclusionsOxygen-sensitive MRI allowed stratification of tumors in terms of local control at 40 Gy, indicating its use as a potential predictive imaging biomarker. Increasing dose to 50 Gy overcame radiation resistance attributable to hypoxia in 50% of tumors.
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Registered trials
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