Evidence map›Paper›PMID 33775818›Full record

SynthesisThe Journal of steroid biochemistry and molecular biology2021

Therapeutic and prognostic role of vitamin D for COVID-19 infection: A systematic review and meta-analysis of 43 observational studies.

Fausto Petrelli, Andrea Luciani, Gianluca Perego, Giuseppina Dognini, Paolo Luigi Colombelli, Antonio Ghidini

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Journal of steroid biochemistry and molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 13 pooled it
14.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 13 syntheses or guidelines pooled it, 105 citations in OpenAlex.

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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Fausto PetrelliOncology Unit, ASST Bergamo Ovest, Treviglio, BG, Italy. Electronic address: faupe@libero.it.
Andrea LucianiOncology Unit, ASST Bergamo Ovest, Treviglio, BG, Italy.
Gianluca PeregoPharmacy Unit, San Raffaele Hospital, Milano, Italy.
Giuseppina DogniniInternal Medicine Unit, ASST Bergamo Ovest, Treviglio, BG, Italy.
Paolo Luigi ColombelliInternal Medicine Unit, ASST Bergamo Ovest, Treviglio, BG, Italy.
Antonio GhidiniOncology Unit, Casa di cura Igea, Milano, Italy.
Azienda Ospedaliera Treviglio · ITCasa di Cura Columbus · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin D modulates the systemic inflammatory response through interaction with immune system. As such, it has a possible protective role against the risk of respiratory tract infections and other diseases. It may be useful in particular, during COVID-19 pandemic. PubMed, the Cochrane Library, and EMBASE were searched from inception until January 31, 2021, for observational or clinical studies reporting the prognosis (and therapeutic effect) of COVID-19 infection in patients with deficient vitamin D levels. The infection rate, severity, and death from COVID-19 infection were pooled to provide an odds ratio with a 95 % confidence interval (OR 95 % CI). An OR > 1 was associated with the worst outcome in deficient compared with nondeficient patients. We assessed the association between vitamin D and risk, severity, and mortality for COVID-19 infection, through a review of 43 observational studies. Among subjects with deficient vitamin D values, risk of COVID-19 infection was higher compared to those with replete values (OR = 1.26; 95 % CI, 1.19-1.34; P < .01). Vitamin D deficiency was also associated with worse severity and higher mortality than in nondeficient patients (OR = 2.6; 95 % CI, 1.84-3.67; P < .01 and OR = 1.22; 95 % CI, 1.04-1.43; P < .01, respectively). Reduced vitamin D values resulted in a higher infection risk, mortality and severity COVID-19 infection. Supplementation may be considered as preventive and therapeutic measure.

Indexed as

Dietary SupplementsPandemicsCOVID-19HumansImmunity, InnateIncidenceObservational Studies as TopicOdds RatioPrognosisRiskSARS-CoV-2Severity of Illness IndexSurvival AnalysisVitamin DVitamin D DeficiencyVitamin DCOVID-19InfectionMeta-analysisMortalityVitamin D3

Identifiers

PMID33775818
PMCPMC7997262
OpenAlexW3152365126

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.