Evidence map›Paper›PMID 33775772›Full record

ArticleFree radical biology & medicine2021

Circulating CD36 is increased in hyperlipidemic mice: Cellular sources and triggers of release.

Sudipta Biswas, Detao Gao, Jessica B Altemus, Umar R Rekhi, Ellen Chang, Maria Febbraio, Tatiana V Byzova, Eugene A Podrez

Open access · greenAbstract read
In one paragraph

Article in Free radical biology & medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Impacts ofCardiovascular therapeutics · 2025
    Pooled it
  2. Review
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  7. Article
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  9. Biomedicines · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Sudipta BiswasDepartment of Inflammation and Immunity, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA.
Detao GaoDepartment of Inflammation and Immunity, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA.
Jessica B AltemusDepartment of Inflammation and Immunity, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA.
Umar R RekhiDepartment of Dentistry, University of Alberta, 11361 87 Avenue, Edmonton, AB, T6G 2E1, Canada.
Ellen ChangDepartment of Biochemistry, Case Western Reserve University, Cleveland, OH, 44106, USA.
Maria FebbraioDepartment of Dentistry, University of Alberta, 11361 87 Avenue, Edmonton, AB, T6G 2E1, Canada.
Tatiana V ByzovaDepartment of Neuroscience, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA.
Eugene A PodrezDepartment of Inflammation and Immunity, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA. Electronic address: podreze@ccf.org.
Cleveland Clinic · USUniversity of Alberta · CACase Western Reserve University · US

Funding

Structure Basis for Talin-mediated Integrin ActivationP01HL073311 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BYZOVA, TATIANA V · 2004 to 2019
$27.4M
Regulation of Integrins in Neovasculature DevelopmentR01HL071625 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BYZOVA, TATIANA V · 2003 to 2021
$7.3M
Pathophysiological Activities of Oxidized PhospholipidsR01HL077213 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI PODREZ, EUGENE A · 2005 to 2018
$4.5M
Platelets in CancerR01HL142772 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BYZOVA, TATIANA V · 2018 to 2021
$2.6M
Role of TLR2 in angiogenesisR01HL145536 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BYZOVA, TATIANA V · 2019 to 2022
$2.6M
Mechanism of atheroprotective function of Akt3 kinaseR01HL126738 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI PODREZ, EUGENE A · 2015 to 2018
$1.6M
NHLBI NIH HHS P01 HL073311NHLBI NIH HHS R01 HL071625NHLBI NIH HHS R01 HL077213NHLBI NIH HHS R01 HL126738NHLBI NIH HHS R01 HL142772NHLBI NIH HHS R01 HL145536
6 · The paper itself

Abstract

CD36 is a multifunctional transmembrane glycoprotein abundantly expressed in several cell types. Recent studies have identified CD36 in circulation (cCD36) in several chronic inflammatory diseases, including type 2 diabetes and chronic kidney disease, and proposed cCD36 to be a biomarker of disease activity. Whether cCD36 is present in hyperlipidemia, a condition characterized by oxidative stress and low-grade inflammation, is not known. In addition, the cellular origin of cCD36 and triggers of CD36 release have not been elucidated. We now demonstrate that plasma cCD36 level is increased in hyperlipidemic ApoE

Indexed as

Diabetes Mellitus, Type 2Endothelial CellsAnimalsCD36 AntigensLipoproteins, LDLMiceMice, KnockoutOxidation-ReductionCD36 AntigensCd36 protein, mouseLipoproteins, LDLAdipocytesCirculating CD36DyslipidemiaEndothelial cellsLipid oxidationMacrophagesOxidized phospholipids (oxPC)PlateletsScavenger receptor

Identifiers

PMID33775772
PMCPMC8085123
OpenAlexW3140276280

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.