Evidence map›Paper›PMID 33775740›Full record

ReviewNeuroscience letters2021

The microtubule cytoskeleton at the synapse.

Julie Parato, Francesca Bartolini

Open access · greenAbstract readReview
In one paragraph

Review in Neuroscience letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 62 citations in OpenAlex.

  1. Review
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  14. Emerging roles for E3 ubiquitin ligases in neural development and disease.Frontiers in cell and developmental biology · 2025
    Review
  15. Review
  16. Underneath the Gut-Brain Axis in IBD-Evidence of the Non-Obvious.International journal of molecular sciences · 2024
    Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Julie ParatoColumbia University Medical Center, Department of Pathology & Cell Biology, 630 West 168(th)Street, P&S 15-421, NY, NY, 10032, United States; SUNY Empire State College, Department of Natural Sciences, 177 Livingston Street, Brooklyn, NY, 11201, United States.
Francesca BartoliniColumbia University Medical Center, Department of Pathology & Cell Biology, 630 West 168(th)Street, P&S 15-421, NY, NY, 10032, United States. Electronic address: fb2131@columbia.edu.
Columbia University Irving Medical Center · USEmpire State University · US

Funding

Pathogenic Roles for Microtubule Stabilization Pathways in Alzheimers diseaseR01AG050658 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Francesca Bartolini · 2016 to 2026
$3.5M
Pathogenic Role of D2 tubulin in Peripheral NeuropathyR21NS120076 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BARTOLINI, FRANCESCA · 2020 to 2020
$446k
Formin-mediated stabilization of dynamic microtubules in the pathogenesis of early-onset familial Alzheimers diseaseR03AG060025 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BARTOLINI, FRANCESCA · 2018 to 2019
$162k
NIA NIH HHS R01 AG050658NIA NIH HHS R03 AG060025NINDS NIH HHS R21 NS120076
6 · The paper itself

Abstract

In neurons, microtubules (MTs) provide routes for transport throughout the cell and structural support for dendrites and axons. Both stable and dynamic MTs are necessary for normal neuronal functions. Research in the last two decades has demonstrated that MTs play additional roles in synaptic structure and function in both pre- and postsynaptic elements. Here, we review current knowledge of the functions that MTs perform in excitatory and inhibitory synapses, as well as in the neuromuscular junction and other specialized synapses, and discuss the implications that this knowledge may have in neurological disease.

Indexed as

Neuronal PlasticityAnimalsDendritic SpinesHumansMicrotubulesNervous System DiseasesSynapsesActive zoneAMPADendritic spinesEn passant boutonsGABA(A)Kif1AMicrotubulesNMDAPostsynaptic densitySynapsesSynaptic vesicleSynaptotagmin IV

Identifiers

PMID33775740
PMCPMC8089059
OpenAlexW3140295936

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.