Observational studyHypertension (Dallas, Tex. : 1979)2021
Comprehensive Comparative Effectiveness and Safety of First-Line β-Blocker Monotherapy in Hypertensive Patients: A Large-Scale Multicenter Observational Study.
Open access · bronzeAbstract readMulticenter StudyObservational Study
In one paragraph
Observational study in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Metabolic Disturbances Associated with Beta-Blocker Therapy: New Insights from a Large-Scale Pharmacovigilance Study.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Beta-blockers for Hypertension: To Be or Not to Be a First-line Drug?Arquivos brasileiros de cardiologia · 2026Article
- Inappropriate use of propranolol among medical students in Palestine: cross-sectional study.BMC medical education · 2025Article
- The Influence of Recreational Hiking on the Prevalence of Cardiovascular and Psychiatric Diseases Among Population of Republic of Serbia.Healthcare (Basel, Switzerland) · 2025Article
- Article
- Symptoms and Conditions in Children and Adults up to 90 Days after SARS-CoV-2 Infection: A Retrospective Observational Study Utilizing the Common Data Model.Journal of clinical medicine · 2024Article
- OHDSI Standardized Vocabularies-a large-scale centralized reference ontology for international data harmonization.Journal of the American Medical Informatics Association : JAMIA · 2024Article
- Utilization patterns of cardiovascular medications in patients with diabetes mellitus; a retrospective cross-sectional study, 2013-17.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2023Article
- Hallmarks of cardiovascular ageing.Nature reviews. Cardiology · 2023Review
- Development of the TrAnsparent ReportinG of observational studies Emulating a Target trial (TARGET) guideline.BMJ open · 2023Article
- The correlation between different antihypertensive treatments and prognosis of cardiovascular disease in hypertensive patients.BMC cardiovascular disorders · 2023Article
- Initial Antihypertensive Regimens in Newly Treated Patients: Real World Evidence From the OneFlorida+ Clinical Research Network.Journal of the American Heart Association · 2023Article
- National Heart Center/Saudi Heart Association 2023 Guidelines on the Management of Hypertension.Journal of the Saudi Heart Association · 2023Article
- Sex differences in the renin-angiotensin-aldosterone system and its roles in hypertension, cardiovascular, and kidney diseases.Frontiers in cardiovascular medicine · 2023Review
- Establishment of an International Evidence Sharing Network Through Common Data Model for Cardiovascular Research.Korean circulation journal · 2022Review
- Analysis of Dual Combination Therapies Used in Treatment of Hypertension in a Multinational Cohort.JAMA network open · 2022Article
- Editorial: Strategies for improving hypertension management.Frontiers in medicine · 2022Article
Corrections and comments
- Commented on by
Authors and funding
14 authors at 13 institutions in 4 countries.
Seng Chan YouDepartment of Biomedical Informatics, Ajou University School of Medicine, Suwon, Korea (S.C.Y., R.W.P.).
Harlan M KrumholzYale University School of Medicine, New Haven, CT (H.M.K.).
Marc A SuchardDepartment of Biostatistics, Fielding School of Public Health (M.A.S., M.J.S.).
Martijn J SchuemieDepartment of Biostatistics, Fielding School of Public Health (M.A.S., M.J.S.).
George HripcsakDepartment of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY (G.H., R.C., S.S., P.B.R.).
RuiJun ChenDepartment of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY (G.H., R.C., S.S., P.B.R.).
Steven SheaDepartment of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY (G.H., R.C., S.S., P.B.R.).
Jon DukeGeorgia Tech Research Institute, Georgia Tech College of Computing, Atlanta (J.D.).
Nicole PrattQuality Use of Medicines and Pharmacy Research Centre, Clinical and Health Sciences, University of South Australia, Adelaide (N.P.).
Christian G ReichReal World Solutions, IQVIA, Cambridge, MA (C.G.R.).
David MadiganDepartment of Statistics, Columbia University, New York, NY (D.M.).
Patrick B RyanJanssen Research and Development, Titusville, NJ (M.J.S., P.B.R.).
Rae Woong ParkDepartment of Biomedical Informatics, Ajou University School of Medicine, Suwon, Korea (S.C.Y., R.W.P.).
Sungha ParkDivision of Cardiology, Severance Cardiovascular Hospital and Integrated Research Center for Cerebrovascular and Cardiovascular Diseases (S.P.), Yonsei University College of Medicine, Seoul, Korea.
Columbia University Irving Medical Center · USAjou University · KRColumbia University · USCornell University · USGeorgia Institute of Technology · USIQ Solutions · USJanssen (United States) · USNewYork–Presbyterian Hospital · USSeverance Hospital · KRUniversity of California, Los Angeles · USUniversity of South Australia · AUYale New Haven Hospital · USYonsei University · KR
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MImplementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1MDISCOVERING AND APPLYING KNOWLEDGE IN CLINICAL DATABASESR01LM006910 · NLM · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HRIPCSAK, GEORGE M · 2000 to 2023
$10.6MNCATS NIH HHS UL1 TR001863NCATS NIH HHS UL1 TR002378NLM NIH HHS R01 LM006910
Abstract
[Figure: see text].
Indexed as
Adrenergic beta-AntagonistsAdultAntihypertensive AgentsAtenololBlood PressureCarvedilolDatabases, FactualFemaleHumansHypertensionMaleMiddle AgedNebivololTreatment OutcomeAdrenergic beta-AntagonistsAntihypertensive AgentsAtenololCarvedilolNebivololantihypertensive agentsatenololblood pressurehypertensionstroke
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.