ArticleClinical research in cardiology : official journal of the German Cardiac Society2021
Physical activity, sedentary behavior and risk of coronary artery disease, myocardial infarction and ischemic stroke: a two-sample Mendelian randomization study.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 4 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 4 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Mendelian randomization studies on ischemic stroke: a field synopsis and systematic review.Journal of translational medicine · 2025Pooled it
- Causal Association Between Sedentary Behaviors and Health Outcomes: A Systematic Review and Meta-Analysis of Mendelian Randomization Studies.Sports medicine (Auckland, N.Z.) · 2024Pooled it
- Genetic association of the gut microbiota with epigenetic clocks mediated by inflammatory cytokines: a Mendelian randomization analysis.Frontiers in immunology · 2024Pooled it
- Genetic evidence for the causal association between type 1 diabetes and the risk of polycystic ovary syndrome.Human genomics · 2023Pooled it
- Joint non-linear dose-response associations of device-measured physical activity and cardiorespiratory fitness with cardiovascular disease: a cohort and Mendelian randomisation study.British journal of sports medicine · 2026Article
- Impact of sedentary behavior and physical activity on stroke risk in a cohort of patients with silent brain infarction.Scientific reports · 2026Article
- Physical activity and myocardial infarction risk: insights from the global burden of disease study 1990-2021 and Mendelian randomization analysis.BMC cardiovascular disorders · 2025Article
- Validation and Refinement of Scores to Predict Stroke Risk: Prospective Cohort Study.JMIR public health and surveillance · 2025Article
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- Relationship Between Physical Activity Levels and Type 2 Diabetes in Adults: Zahedan Adult Cohort Study, Iran.Health science reports · 2025Article
- The Relationship Between Hypothyroidism and Pneumonia and Possible Prevention and Treatment Measures.International journal of general medicine · 2025Article
- Associations between physical activity and heart disease among middle-aged and older Chinese adults.Frontiers in cardiovascular medicine · 2025Article
- Association between healthy lifestyle and the risk of ischemic stroke among elderly adults with hypertension: a cross-sectional study in China.Frontiers in nutrition · 2025Article
- Causal relationship between 731 immune cells and the risk of diabetic nephropathy: a two‑sample bidirectional Mendelian randomization study.Renal failure · 2024Article
- Observational and genetic associations between cardiorespiratory fitness and age-related diseases: longitudinal analyses in the UK Biobank study.The EPMA journal · 2024Article
- Progress Analysis of Personalized Antiplatelet Therapy in Patients with Coronary Heart Disease Undergoing Interventional Therapy.Reviews in cardiovascular medicine · 2024Review
- The association between metabolic syndrome and lung cancer risk: a Mendelian randomization study.Scientific reports · 2024Article
- Physical activity and the risk of developing 8 age-related diseases: epidemiological and Mendelian randomization studies.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2024Article
- Causal associations between frailty and low back pain: a bidirectional two-sample mendelian randomization study.Aging clinical and experimental research · 2024Article
- Causal relationship of interleukin-6 and its receptor on sarcopenia traits using mendelian randomization.Nutrition journal · 2024Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsObservational evidence suggests that physical activity (PA) is inversely and sedentarism positively related with cardiovascular disease risk. We performed a two-sample Mendelian randomization (MR) analysis to examine whether genetically predicted PA and sedentary behavior are related to coronary artery disease, myocardial infarction, and ischemic stroke. METHODS AND
resultsWe used single nucleotide polymorphisms (SNPs) associated with self-reported moderate to vigorous PA (n = 17), accelerometer based PA (n = 7) and accelerometer fraction of accelerations > 425 milli-gravities (n = 7) as well as sedentary behavior (n = 6) in the UK Biobank as instrumental variables in a two sample MR approach to assess whether these exposures are related to coronary artery disease and myocardial infarction in the CARDIoGRAMplusC4D genome-wide association study (GWAS) or ischemic stroke in the MEGASTROKE GWAS. The study population included 42,096 cases of coronary artery disease (99,121 controls), 27,509 cases of myocardial infarction (99,121 controls), and 34,217 cases of ischemic stroke (404,630 controls). We found no associations between genetically predicted self-reported moderate to vigorous PA, accelerometer-based PA or accelerometer fraction of accelerations > 425 milli-gravities as well as sedentary behavior with coronary artery disease, myocardial infarction, and ischemic stroke.
conclusionsThese results do not support a causal relationship between PA and sedentary behavior with risk of coronary artery disease, myocardial infarction, and ischemic stroke. Hence, previous observational studies may have been biased.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.