Evidence map›Paper›PMID 33774685›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2021

Total metabolic tumor volume and spleen metabolism on baseline [18F]-FDG PET/CT as independent prognostic biomarkers of recurrence in resected breast cancer.

Romain-David Seban, Roman Rouzier, Aurelien Latouche, Nicolas Deleval, Jean-Marc Guinebretiere, Irene Buvat, Francois-Clement Bidard, Laurence Champion

Abstract read
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Article in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Organ Crosstalk: The Role of Spleen.Phenomics (Cham, Switzerland) · 2025
    Review
  6. BaselineLa Radiologia medica · 2025
    Article
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  13. Hyperpolarized [1-European radiology experimental · 2024
    Article
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  16. Evaluating the correlation between pretreatmentPathology oncology research : POR · 2024
    Article
  17. EJNMMI research · 2023
    Article
  18. Article
  19. Advances in PET/CT Imaging for Breast Cancer.Journal of clinical medicine · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Romain-David SebanDepartment of Nuclear Medicine, Institut Curie, 92210, Saint-Cloud, France. romain.seban@gmail.com.ORCID 0000-0002-2584-5478
Roman RouzierDepartment of Surgery, Institut Curie, PSL Research University, 75005 Paris &, 92210, Saint-Cloud, France.
Aurelien LatoucheBioinformatics and Computational Systems Biology of Cancer, PSL Research University, Mines Paris Tech, INSERM U900, 75005, Paris, France.
Nicolas DelevalDepartment of Nuclear Medicine, Institut Curie, 92210, Saint-Cloud, France.
Jean-Marc GuinebretiereDepartment of Pathology, Institut Curie, 92210, Saint-Cloud, France.
Irene BuvatLaboratoire d'Imagerie Translationnelle en Oncologie, Inserm U1288, PSL Research University, Institut Curie, 91400, Orsay, France.
Francois-Clement BidardDepartment of Medical Oncology, Institut Curie, PSL Research University, 75005 Paris &, 92210, Saint-Cloud, France.
Laurence ChampionDepartment of Nuclear Medicine, Institut Curie, 92210, Saint-Cloud, France.
Inserm · FRInstitut Curie · FRUniversité Paris Sciences et Lettres · FRConservatoire National des Arts et Métiers · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe evaluated whether biomarkers on baseline [

methodsIn this retrospective single-center study, we included consecutive patients with non-metastatic breast cancer of NST who underwent [

resultsThree hundred and three women were eligible, including 93 (31%) with triple-negative breast carcinoma. After a median follow-up of 6.2 years, 56 and 35 patients experienced recurrence and death, respectively. The 5y-RFS rate was 86%. In multivariable analyses, high TMTV (>20 cm3) and high SLR (>0.76) were associated with shorter 5y-RFS (HR 2.4, 95%CI 1.3-4.5, and HR 1.9, 95%CI 1.0-3.6). In logistic regression, high SLR was the only independent factor associated with low stromal TILs (OR 2.8, 95%CI 1.4-5.7).

conclusionHigh total metabolic tumor volume and high spleen glucose metabolism on baseline [

Indexed as

Breast NeoplasmsFluorodeoxyglucose F18BiomarkersFemaleHumansNeoplasm Recurrence, LocalPositron Emission Tomography Computed TomographyPrognosisRetrospective StudiesSpleenTumor BurdenTumor MicroenvironmentBiomarkersFluorodeoxyglucose F18[18F]-FDG PET/CTInvasive breast cancer of no special typePrognosisSpleen glucose metabolismStromal tumor-infiltrating lymphocytesTotal metabolic tumor volume

Identifiers

PMID33774685
OpenAlexW3149764185

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.