Observational studyRespiration; international review of thoracic diseases
Use of Ventilation-Perfusion Single-Photon Emission Computed Tomography to Select the Target Lobe for Endobronchial Valve Lung Volume Reduction.
Observational study in Respiration; international review of thoracic diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Role of quantitative ventilation/perfusion scan (qVQ) in the pre-treatment assessment of bronchoscopic lung volume reduction with endobronchial valves (BLVR-EBV) for emphysema and the pre-operative assessment for lung cancer: a systematic review.Journal of thoracic disease · 2026Review
- Sequelae of bronchoscopic lung volume reduction with endobronchial valves evaluated with quantitative VQ SPECT CT and quantitative CT-a sub analysis of the EMPHYSISE study.Journal of thoracic disease · 2026Article
- The value of V/Q SPECT/CT lobar quantitation for pre-treatment assessment of lung malignancy.Journal of thoracic disease · 2026Article
- Regional ventilation-perfusion changes after endobronchial valve therapy assessed by single-photon emission computed tomography in adults with severe COPD.Scientific reports · 2026Article
- A Comprehensive Approach to Lung Volume Reduction Encompassing Surgical and Endobronchial Treatment of Severe Emphysema.CHEST pulmonary · 2025Article
- Bronchoscopic lung volume reduction: model for assisted target lobe selection.BMJ open respiratory research · 2025Article
- Case Report: Late paradoxical intrapulmonary shunt after endoscopic lung volume reduction with endobronchial valves for severe emphysema.Frontiers in medicine · 2025Article
- European Respiratory Society International Congress, Paris, 2018: highlights from the Clinical Assembly.ERJ open research · 2019Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundQuantitative planar ventilation-perfusion (VQ) has a complementary role in target lobe selection for endobronchial valve lung volume reduction (EBV-LVR), especially in homogenous disease. We investigated a novel method of lung lobar quantitation using VQ single-photon emission computed tomography (SPECT) with computed tomography (CT) to generate a parameter called the ventilation-perfusion differential index (VQDI).
aimThe aim of this study was to validate VQDI as a parameter for target lobe selection in EBV-LVR against the gold standard test of quantitative computed tomography (qCT).
methodsThis study was a prospective, multi-centre, single-blinded, observational study of EBV-LVR patients. Baseline and 3-month post intervention VQ SPECT and qCT were performed. The target lobe was chosen using qCT and planar VQ report (CTTL) whilst blinded to VQDI. Post EBV-LVR, our nuclear physician, blinded to CTTL, selected a target lobe using deidentified VQDI (VQDITL). Inter-rater agreement between CTTL and VQDITL was calculated by Kappa statistic. Treatment outcomes were analysed with a linear mixed-effects model.
resultsThere was a high concordance between CTTL and VQDITL in 16 patients (89%, Kappa statistic = 0.85). Post EBV-LVR, our subjects showed significant changes in FEV1 (mean difference [MD] +150 mL, p < 0.001), target lobe volume reduction (MD -973 mL, p < 0.001), residual volume (MD -800 mL, p < 0.001), and St. George's Respiratory Questionnaire score (MD -11, p = 0.001). Improvements in 6-minute walk distances did not reach statistical significance.
conclusionIn this study of treatment responders, EBV-LVR target lobe selection using VQDI concurs with qCT and thus supports its value for this purpose. It complements qCT and may potentially be of synergistic value especially in homogenous emphysema.
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