Evidence map›Paper›PMID 33774496›Full record

ArticleEnvironment international2021

Contribution of trace element exposure to gestational diabetes mellitus through disturbing the gut microbiome.

Yuqing Zhang, Ting Chen, Yiyun Zhang, Qi Hu, Xu Wang, Hang Chang, Jian-Hua Mao, Antoine M Snijders, Yankai Xia

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Pooled it
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  4. Review
  5. Article
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  7. Article
  8. Article
  9. Article
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  11. Joint effects of prenatal PMFrontiers in public health · 2025
    Article
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  14. Article
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  16. Article
  17. Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024
    Article
  18. Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Yuqing ZhangNanjing Maternity and Child Health Care Institute, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Hospital, Nanjing, China; State Key Laboratory of Reproductive Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.
Ting ChenNanjing Maternity and Child Health Care Institute, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Hospital, Nanjing, China; State Key Laboratory of Reproductive Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.
Yiyun ZhangState Key Laboratory of Reproductive Medicine, School of Public Health, Nanjing Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China.
Qi HuState Key Laboratory of Reproductive Medicine, School of Public Health, Nanjing Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China.
Xu WangDepartment of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Hang ChangBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Jian-Hua MaoBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Antoine M SnijdersBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. Electronic address: amsnijders@lbl.gov.
Yankai XiaState Key Laboratory of Reproductive Medicine, School of Public Health, Nanjing Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China. Electronic address: yankaixia@njmu.edu.cn.
Lawrence Berkeley National Laboratory · USNanjing Maternity and Child Health Care Hospital · CNMinistry of Education · KRSecond Affiliated Hospital of Nanjing Medical University · CN

Funding

Role of the gut microbiome in pesticide-induced effects on child neurodevelopmentR01ES031322 · NIEHS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI MAO, JIAN-HUA · 2020 to 2024
$1.4M
NIEHS NIH HHS R01 ES031322
6 · The paper itself

Abstract

backgroundA healthy gut microbiome is critical for glucose metabolism during pregnancy. In vivo studies indicate that trace element affects the composition and function of the gut microbiome and potentially leads to metabolic disorders but their relationships are largely unknown. We aimed to investigate whether the gut microbiome plays a role in the relationship between trace element exposure and gestational diabetes mellitus (GDM).

methodsIn a prospective cohort study, serum levels of 22 trace elements and the fecal gut microbiome composition were assessed in 837 pregnant women in the second trimester between 22 and 24 weeks of pregnancy prior to GDM diagnosis. Regression and mediation analysis were used to explore the link between element exposure, the gut microbiome, and GDM.

results128 pregnant women (15.3%) were diagnosed with GDM. No individual trace elements were found significantly associated with GDM. In contrast, the composition of the gut microbiome was dramatically altered in women later diagnosed with GDM and characterized by lower alpha diversity and lower abundance of co-abundance groups (CAGs) composed of genera belonging to Ruminococcaceae, Coriobacteriales, and Lachnospiraceae. Rubidium (Rb) was positively associated with alpha diversity indices while mercury (Hg) and vanadium (V) showed negative associations. Elements including rubidium (Rb), thallium (Tl), arsenic (As), and antimony (Sb) were significantly correlated with GDM-related CAGs and mediation analysis revealed that Rb and Sb were inversely related to GDM risk by altering abundance levels of CAGs enriched for Lachnospiraceae, Coriobacteriales, and Ruminococcaceae.

conclusionOur study indicates that trace element exposure is associated with specific gut microbiome features that may contribute to GDM development, which could provide a new avenue for intervening in environmental exposure-related GDM.

Indexed as

Diabetes, GestationalGastrointestinal MicrobiomeTrace ElementsFecesFemaleHumansPregnancyProspective StudiesTrace ElementsGestational diabetes mellitusGut microbiomeMediation effectTrace element

Identifiers

PMID33774496
PMCPMC8638703
OpenAlexW3139811961

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.