Evidence map›Paper›PMID 33773590›Full record

ArticleBMC neurology2021

Plasma D-dimer level is associated with clinical outcomes in patients with atrial fibrillation related acute ischemic stroke after pneumonia.

Xu Yang, Taoli Lu, Zhanli Qu, Yi Zhang, Pingping Liu, Ying Ma

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  4. Review
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  7. Braden scale for predicting pneumonia after spontaneous intracerebral hemorrhage.Revista da Associacao Medica Brasileira (1992) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Xu YangDepartment of Neurology, Nanchong Central Hospital; The Second Clinical Medical School, North Sichuan Medical College, Nanchong, 637000, Sichuan, China. 2399548051@qq.com.
Taoli LuDepartment of Neurology, Chengdu second people's hospital, Chengdu, 610015, Sichuan, China.
Zhanli QuDepartment of Neurology, Nanchong Central Hospital; The Second Clinical Medical School, North Sichuan Medical College, Nanchong, 637000, Sichuan, China.
Yi ZhangDepartment of Neurology, Nanchong Central Hospital; The Second Clinical Medical School, North Sichuan Medical College, Nanchong, 637000, Sichuan, China.
Pingping LiuDepartment of Neurology, Nanchong Central Hospital; The Second Clinical Medical School, North Sichuan Medical College, Nanchong, 637000, Sichuan, China.
Ying MaDepartment of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, Sichuan, China.
Nanchong Central Hospital · CNNorth Sichuan Medical University · CNAffiliated Hospital of North Sichuan Medical College · CNChengdu Second People's Hospital · CN

Funding

The youth innovation subject in medical research of Sichuan province Q16004
6 · The paper itself

Abstract

backgroundPneumonia is related to poor prognosis in acute ischemic stroke (AIS), and its risk might be higher in atrial fibrillation (AF) related AIS with elevated plasma D-dimer. The aim of our study was to investigate the prognostic value of D-dimer for predicting clinical outcome of AF-related AIS with pneumonia.

methodAF-related AIS patients with pneumonia were prospectively enrolled. Receiver operating characteristic (ROC) curve was used to determine the optimal D-dimer point for 3-month mortality and death/severe disability. The associations between the D-dimer and 3-month mortality and death/severe disability were assessed by multivariable logistic regression analysis.

resultsA total of 415 patients were enrolled in this study. ROC curve analysis showed that the optimal cut point of D-dimer for 3-month death/severe disability and mortality were D-dimer≥2.35 mg/l and D-dimer≥3.35 mg/l, respectively. Multivariable logistic regression analysis showed that D-dimer≥2.35 mg/l [adjusted odds ratio (aOR) 5.99, 95% confidence interval (CI): 3.04-11.83, P<0.001], higher NIHISS score (aOR:1.53, 95% CI: 1.38-1.69, P<0.001) and larger infarct volume (aOR 1.01, 95% CI: 1.01-1.02, P<0.001) were associated with increased risk of 3-month death/severe disability), and anticoagulant was associated with decreased risk of death/severe disability (aOR:0.21, 95% CI: 0.09-0.47, P<0.001). Higher NIHISS score (aOR:1.64, 95% CI: 1.38-1.94, P<0.001), older age (aOR 1.08, 95% CI: 1.02-1.14, P = 0.007), D-dimer≥3.35 mg/l (OR 8.49, 95% CI: 4.13-17.84,P<0.001), larger infarct volume (aOR 1.02, 95% CI: 1.00-1.03, P = 0.014), and higher CRUB-65 score (aOR 6.43, 95% CI: 3.10-13.34, P<0.001) were associated with increased risk of 3-month mortality.

conclusionsAF-related AIS patients with concurrent high D-dimer and pneumonia increased risk of 3-month mortality and death/severe disability, plasma D-dimer may have predictive value in outcome after AF-related AIS with pneumonia.

Indexed as

AgedAnticoagulantsAtrial FibrillationBiomarkersBrain IschemiaChinaFemaleFibrin Fibrinogen Degradation ProductsHumansIschemic StrokeMaleMiddle AgedOdds RatioPersons with DisabilitiesPlasmaPneumoniaAnticoagulantsBiomarkersFibrin Fibrinogen Degradation Productsfibrin fragment DAcute ischemic strokeAtrial fibrillationD-dimerOutcomePneumonia

Identifiers

PMID33773590
PMCPMC8004437
OpenAlexW3150256861

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.