Evidence map›Paper›PMID 33773580›Full record

Trial reportBMC anesthesiology2021

Lidocaine combined with magnesium sulfate preserved hemodynamic stability during general anesthesia without prolonging neuromuscular blockade: a randomized, double-blind, controlled trial.

Waynice N Paula-Garcia, Gustavo H Oliveira-Paula, Hans Donald de Boer, Luis Vicente Garcia

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02483611 (Effect of Intravenous Infusion of Magnesium Sulfate Associated or Not to Lidocaine On the Neuromuscular Blockade Induced by Muscle Relaxant Cistracurium), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02483611 phase4completednot on this map

Effect of Intravenous Infusion of Magnesium Sulfate Associated or Not to Lidocaine On the Neuromuscular Blockade Induced by Muscle Relaxant Cistracurium

TypeinterventionalSponsorUniversity of Sao PauloRan2015 to 2015Enrolled48ConditionsNeuromuscular BlockArmsMagnesium Sulfate, Lidocaine, Isotonic Solution, Cisatracurium
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Waynice N Paula-GarciaDepartment of Orthopedics and Anesthesiology, Faculty of Medicine of Ribeirao Preto, University of São Paulo, Ribeirão Preto, SP, 14049900, Brazil. wgarcia@fmrp.usp.br.ORCID 0000-0003-0020-5295
Gustavo H Oliveira-PaulaAlbert Einstein College of Medicine, New York 1300 Morris Park Ave, The Bronx, NY, 10461, USA.
Hans Donald de BoerDepartment of Anesthesiology, Pain Medicine and Procedural Sedation and Analgesia, Martini General Hospital Groningen, van Swietenplein 1, 9728, NT, Groningen, The Netherlands.
Luis Vicente GarciaDepartment of Orthopedics and Anesthesiology, Faculty of Medicine of Ribeirao Preto, University of São Paulo, Ribeirão Preto, SP, 14049900, Brazil.
Albert Einstein College of Medicine · USMartini Ziekenhuis · NLUniversidade de Ribeirão Preto · BRUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLidocaine and magnesium sulfate have become increasingly utilized in general anesthesia. The present study evaluated the effects of these drugs, isolated or combined, on hemodynamic parameters as well as on the cisatracurium-induced neuromuscular blockade (NMB).

methodsAt a university hospital, 64 patients, ASA physical status I and II, undergoing elective surgery with similar pain stimuli were randomly assigned to four groups. Patients received a bolus of lidocaine and magnesium sulfate before the tracheal intubation and a continuous infusion during the operation as follows: 3 mg.kg

resultsThe magnesium sulfate significantly prolonged all NMB recovery features, without changing the speed of onset of cisatracurium. The addition of lidocaine to Magnesium Sulfate did not influence the cisatracurium neuromuscular blockade. A similar finding was observed when this drug was used alone, with a significantly smaller fluctuation of mean arterial pressure (MAP) and heart rate (HR) measures during anesthesia induction and maintenance. Interestingly, the percentage of patients who achieved a TOFR of 90% without reaching T1-95% was higher in the M and ML groups. Than in the C and L groups. There were no adverse events reported in this study.

conclusionIntravenous lidocaine plays a significant role in the hemodynamic stability of patients under general anesthesia without exerting any additional impact on the NMB, even combined with magnesium sulfate. Aside from prolonging all NMB recovery characteristics without altering the onset speed, magnesium sulfate enhances the TOF recovery rate without T1 recovery. Our findings may aid clinical decisions involving the use of these drugs by encouraging their association in multimodal anesthesia or other therapeutic purposes.

trial registrationNCT02483611 (registration date: 06-29-2015).

Indexed as

Anesthesia, GeneralAdultAnalgesicsAnesthetics, LocalArterial PressureAtracuriumDouble-Blind MethodDrug CombinationsFemaleHeart RateHumansInfusions, IntravenousLidocaineMagnesium SulfateMaleNeuromuscular BlockadeAnalgesicsAnesthetics, LocalAtracuriumcisatracuriumDrug CombinationsLidocaineMagnesium SulfateNeuromuscular Blocking AgentsGeneral anesthesiaHemodynamic parametersLidocaineMagnesium sulfateNeuromuscular blockade

Identifiers

PMID33773580
PMCPMC8004390
OpenAlexW3141271686

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.