Evidence map›Paper›PMID 33773539›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2021

Chemotherapy Negates the Effect of SDF1 mRNA to Distant Metastasis and Poor Overall Survival in Breast Cancer Patients.

Kristanto Yuli Yarso, Monica Bellynda, Akhmad Azmiardi, Brian Wasita, Didik Setyo Heriyanto, Indwiani Astuti, Mohammad Hakimi, Teguh Aryandono

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In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kristanto Yuli YarsoDepartment of Surgery, Oncology Division, Medical Faculty, Sebelas Maret University, Indonesia.ORCID 0000-0003-4514-4676
Monica BellyndaDepartment of Surgery, Medical Faculty, Sebelas Maret University, Indonesia.ORCID MonicaBellynda17
Akhmad AzmiardiDepartment of Public Health, Faculty of Public Health, Veteran Bangun Nusantara Sukoharjo University, Indonesia.
Brian WasitaDepartment of Anatomical Pathology, Medical Faculty, Sebelas Maret University, Indonesia.
Didik Setyo HeriyantoDepartment of Anatomical Pathology, Medical Faculty, Gadjah Mada University, Indonesia.
Indwiani AstutiDepartment of Pharmacology and Therapy, Medical Faculty, Gadjah Mada University, Indonesia.
Mohammad HakimiDepartment of Obstetrics and Gynecology, Medical Faculty, Gadjah Mada University, Indonesia.
Teguh AryandonoDepartment of Surgery, Oncology Division, Medical Faculty, Gadjah Mada University, Indonesia.ORCID 0000-0002-1143-4125

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveInvestigate the effect of SDF1a, nuclear, and cytoplasmic CXCR4 breast cancer tissue on metastasis and overall survival in patients with complete-chemotherapy and no-chemotherapy.

methodsCohort ambidirectional design was employed with survival analysis that followed the patient's diagnosis until obtaining the outcome, distant metastasis, or death. We analyzed samples in three groups (all-patient, no-chemotherapy, and complete-chemotherapy groups).  Breast cancer cell nuclear and cytoplasm expressions of CXCR4 protein were examined using immunohistochemistry. Amplification of mRNA SDF1a of breast cancer tissue was examined using rtPCR on 131 samples from the same initial paraffin block.

resultsIn the distant metastasis and Overall Survival (OS) analysis, there was no correlation between cytoplasmic and nuclear CXCR4 in all-patient, no-chemotherapy, and complete-chemotherapy groups. SDF1a was significantly correlated to shorter distant metastasis and poor OS in the all-patient (p=0.004 and p=0.04, respectively) and no-chemotherapy group (p=0.008 and p=0.026, respectively). However, in the complete-chemotherapy group, SDF1a was not correlated to either metastasis (p=0.527) or OS (p=0.993), advanced stage demonstrated a strong association on shorter distant metastatic in no-chemotherapy (p=0.021) and complete-chemotherapy group (p=0.004) and also poor OS in both groups (p=0.006 and p=0.002, respectively). The hormone receptor showed a protective effect on the no-chemotherapy group's OS (p= 0.019). Meanwhile, not undergoing chemotherapy was associated with poor OS in the all-patient group (p= 0.011).

conclusionSDF1a mRNA amplification has a significant correlation with the occurrence of metastasis and OS in all-patient and no-chemotherapy group. Undergoing chemotherapy negates the effect of SDF1a for distant metastasis and OS.

Indexed as

Chemotherapy, AdjuvantMastectomyAntineoplastic AgentsBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, LobularCarcinoma, MedullaryChemokine CXCL12FemaleHumansMiddle AgedNeoplasm MetastasisPrognosisReceptors, CXCR4RNA, MessengerSurvival RateAntineoplastic AgentsChemokine CXCL12CXCL12 protein, humanCXCR4 protein, humanReceptors, CXCR4RNA, Messengerbreast cancerChemotherapyCXCR4MetastasismRNA SDF1a

Identifiers

PMID33773539
PMCPMC8286657

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.