ArticleImmunity2021
Two sequential activation modules control the differentiation of protective T helper-1 (Th1) cells.
Open access · bronzeAbstract read
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Article in Immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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0cells of the map it votes in
41citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
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Who cites it
41 citing papers in PubMed, 70 citations in OpenAlex.
- Tissue-specific clonal selection and differentiation of CD4⁺ T cells during infection.Nature immunology · 2026Article
- Immune checkpoints in a genetically engineered mouse model of spontaneous autoimmune uveitis.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Type I interferons in tuberculosis pathogenesis and prevention.Trends in microbiology · 2026Review
- Delayed type I interferon response and the subsequent out-of-sequence cytokine signal inhibit T cell induction in non-surviving Ebola virus-infected patients.Frontiers in immunology · 2026Article
- A time-gated PKA-CREB signaling circuit licenses IL-12 responsiveness and Th1 fate in CD4Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- TIM-3 ameliorates host responses to Salmonella infection by controlling iron driven CD4EBioMedicine · 2025Article
- Cell-intrinsic CD4 T cell tolerance: a new frontier in therapy?Trends in immunology · 2025Review
- T Cell Responses to Influenza Infections in Cattle.Viruses · 2025Review
- Lymphatic chain gradients regulate the magnitude and heterogeneity of T cell responses to vaccination.The Journal of experimental medicine · 2025Article
- Regulation of CD4 + T cell differentiation and function by glucose metabolism.Genes and immunity · 2025Review
- KMT2D coordinates antiviral CD4Cell reports · 2025Article
- T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses.The EMBO journal · 2025Article
- Neuron-restricted cytomegalovirus latency in the central nervous system regulated by CD4Journal of neuroinflammation · 2025Article
- STIM1-mediated NFAT signaling synergizes with STAT1 to control T-bet expression and TNature immunology · 2025Article
- Calcium signaling is essential for T helper 1 cell differentiation.Nature immunology · 2025Article
- A minority of Th1 and Tfh effector cells express survival genes shared by memory cell progeny that require IL-7 or TCR signaling to persist.Cell reports · 2025Article
- T cell-derived IFN-γ Suppresses T Follicular Helper Cell Differentiation and Antibody Responses.bioRxiv : the preprint server for biology · 2025Article
- Trypanosoma vivax elicits both Th1 and Th2 immunological responses in experimentally infected cattle.PloS one · 2025Article
- Microbiome-immune crosstalk in allergic rhinitis: lung and intestinal microbiota mechanisms.Frontiers in microbiology · 2025Review
- Integrative analysis of ASXL family genes reveals ASXL2 as an immunoregulatory molecule in head and neck squamous cell carcinoma.Scientific reports · 2024Article
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Authors and funding
8 authors at 1 institution in 1 country.
Peter D KruegerCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55455 USA.
Michael F GoldbergCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55455 USA.
Sung-Wook HongCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55455 USA.
Kevin C OsumCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55455 USA.
Ryan A LangloisCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55455 USA.
Dmitri I KotovCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55455 USA.
Thamotharampillai DileepanCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55455 USA.
Marc K JenkinsCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55455 USA. Electronic address: jenki002@umn.edu.
University of Minnesota Medical Center · US
Funding
Type I interferons in tolerance in the steady stateP01AI035296 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HOGQUIST, KRISTIN A. · 1993 to 2023
$31.1MTRAINING IN HEMOGLOBIN &CELL MEMBRANE RESEARCHT32HL007062 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Jeffrey S. Miller, Gregory M Vercellotti · 1985 to 2026
$10.3MTRACKING CD4+ MEMORY T CELLS IN VIVOR01AI039614 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JENKINS, MARC KEVIN · 1996 to 2023
$8.7MIMMUNOLOGY TRAINING PROGRAMT32AI007313 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Carla Rothlin · 1989 to 2026
$5.7MCOSTIMULATORY SIGNALS IN CD4+ T-CELL ACTIVATIONR01AI027998 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JENKINS, MARC KEVIN · 1989 to 2022
$4.5MProtective CD4+ T CellsR01AI103760 · NIAID · UNIVERSITY OF MINNESOTA · PI JENKINS, MARC KEVIN · 2013 to 2022
$4.2MMinnesota Training Program in VirologyT32AI083196 · NIAID · UNIVERSITY OF MINNESOTA · PI Louis M Mansky · 2010 to 2026
$3.2MNHLBI NIH HHS T32 HL007062NIAID NIH HHS P01 AI035296NIAID NIH HHS R01 AI027998NIAID NIH HHS R01 AI039614NIAID NIH HHS R01 AI103760NIAID NIH HHS T32 AI007313NIAID NIH HHS T32 AI083196
Abstract
Interferon-γ (IFN-γ)-producing CD4
Indexed as
AnimalsCD4-Positive T-LymphocytesCell DifferentiationCell LineDrosophilaFemaleInterferon-gammaInterleukin-12Lymphocyte ActivationMaleMiceMice, Inbred C57BLTh1 CellsT-Lymphocytes, Helper-InducerInterferon-gammaInterleukin-12IL-12infectioninfluenzaSalmonellaTfhTh1ZEB2
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.