ArticlePlant biotechnology journal2021
Discovery and characterization of small molecule inhibitors of cystathionine gamma-synthase with in planta activity.
Article in Plant biotechnology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Article
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- Benzoic and salicylic acids inhibit β-substituted alanine synthase 4;1 in common bean.Plant physiology · 2025Article
- Identification of Motilimonas thetidivivens sp. nov., a Novel Marine Gammaproteobacterium.Current microbiology · 2025Article
- Discovery and characterization of small molecule inhibitors of cystathionine gamma-synthase with in planta activity.Plant biotechnology journal · 2021Article
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Authors and funding
10 authors at 2 institutions in 1 country.
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Abstract
The synthesis of essential amino acids in plants is pivotal for their viability and growth, and these cellular pathways are therefore targeted for the discovery of new molecules for weed control. Herein, we describe the discovery and design of small molecule inhibitors of cystathionine gamma-synthase, a key enzyme in the biosynthesis of methionine. Based on in silico screening and filtering of a large molecular database followed by the in vitro selection of molecules, we identified small molecules capable of binding the target enzyme. Molecular modelling of the interaction and direct biophysical binding enabled us to explore a focussed chemical expansion set of molecules characterized by an active phenyl-benzamide chemical group. These molecules are bio-active and efficiently inhibit the viability of BY-2 tobacco cells and seedlings growth of Arabidopsis thaliana on agar plates.
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