ArticleAmerican journal of physical anthropology2021
Skin deep: The decoupling of genetic admixture levels from phenotypes that differed between source populations.
Article in American journal of physical anthropology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Article
- The genomic footprints of migration: how ancient DNA reveals our history of mobility.Genome biology · 2025Review
- Nested Admixture During and After the Trans-Atlantic Slave Trade on the Island of São Tomé.Molecular biology and evolution · 2025Article
- Differentiating mechanism from outcome for ancestry-assortative mating in admixed human populations.Genetics · 2025Article
- A Macaque Model for the Effects of Hybridization on Body Size.American journal of biological anthropology · 2025Article
- Differentiating mechanism from outcome for ancestry-assortative mating in admixed human populations.bioRxiv : the preprint server for biology · 2024Article
- Counting the genetic ancestors from source populations in members of an admixed population.Genetics · 2024Article
- Article
- Polygenic prediction across populations is influenced by ancestry, genetic architecture, and methodology.Cell genomics · 2023Article
- On the number of genealogical ancestors tracing to the source groups of an admixed population.Genetics · 2023Article
- Human genetic admixture through the lens of population genomics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
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4 authors.
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Abstract
objectivesIn genetic admixture processes, source groups for an admixed population possess distinct patterns of genotype and phenotype at the onset of admixture. Particularly in the context of recent and ongoing admixture, such differences are sometimes taken to serve as markers of ancestry for individuals-that is, phenotypes initially associated with the ancestral background in one source population are assumed to continue to reflect ancestry in that population. Such phenotypes might possess ongoing significance in social categorizations of individuals, owing in part to perceived continuing correlations with ancestry. However, genotypes or phenotypes initially associated with ancestry in one specific source population have been seen to decouple from overall admixture levels, so that they no longer serve as proxies for genetic ancestry. Here, we aim to develop an understanding of the joint dynamics of admixture levels and phenotype distributions in an admixed population.
methodsWe devise a mechanistic model, consisting of an admixture model, a quantitative trait model, and a mating model. We analyze the behavior of the mechanistic model in relation to the model parameters.
resultsWe find that it is possible for the decoupling of genetic ancestry and phenotype to proceed quickly, and that it occurs faster if the phenotype is driven by fewer loci. Positive assortative mating attenuates the process of dissociation relative to a scenario in which mating is random with respect to genetic admixture and with respect to phenotype.
conclusionsThe mechanistic framework suggests that in an admixed population, a trait that initially differed between source populations might serve as a reliable proxy for ancestry for only a short time, especially if the trait is determined by few loci. It follows that a social categorization based on such a trait is increasingly uninformative about genetic ancestry and about other traits that differed between source populations at the onset of admixture.
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