Evidence map›Paper›PMID 33772424›Full record

ArticleJournal of molecular neuroscience : MN2021

Decreased AQP4 Expression Aggravates ɑ-Synuclein Pathology in Parkinson's Disease Mice, Possibly via Impaired Glymphatic Clearance.

Huili Cui, Wenkang Wang, Xinhui Zheng, Danhao Xia, Han Liu, Chi Qin, Haiyan Tian, Junfang Teng

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular neuroscience : MN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.

  1. Pooled it
  2. High frame ratebioRxiv : the preprint server for biology · 2026
    Article
  3. Shared genetic architecture between DTI-ALPS traits and neurodegenerative diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Huili CuiDepartment of Neurology, Institute of Parkinson and Movement Disorder, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Wenkang WangDepartment of Orthopedics, Graduate School of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.
Xinhui ZhengDepartment of Orthopedics, Graduate School of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.
Danhao XiaDepartment of Neurology, Institute of Parkinson and Movement Disorder, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Han LiuDepartment of Neurology, Institute of Parkinson and Movement Disorder, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Chi QinDepartment of Neurology, Institute of Parkinson and Movement Disorder, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Haiyan TianDepartment of Neurology, Institute of Parkinson and Movement Disorder, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Junfang TengDepartment of Neurology, Institute of Parkinson and Movement Disorder, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. anypass0725@163.com.ORCID http://orcid.org/0000-0002-8055-7292
First Affiliated Hospital of Zhengzhou University · CNNingxia Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathological hallmarks of Parkinson's disease (PD), a neurodegenerative disorder, are the selective loss of dopamine neurons in the substantia nigra pars compacta (SNpc) and the presence of α-synuclein (α-syn) aggregates in the form of Lewy bodies/Lewy neurites (LBs/LNs) in neurons. Recent studies have indicated that aquaporin 4 (AQP4), as a predominant water channel protein in the brain, is involved in the progression of Parkinson's disease (PD). However, it remains unclear whether AQP4 expression affects α-syn pathology in Parkinson's disease. In this study, we established a progressive PD model by subjecting AQP4 null (AQP4

Indexed as

alpha-SynucleinAnimalsAquaporin 4Glymphatic SystemLewy BodiesMaleMiceMice, Inbred C57BLParkinson DiseaseSubstantia Nigraalpha-SynucleinAqp4 protein, mouseAquaporin 4Aquaporin 4Glymphatic clearanceNeurodegenerationParkinson’s diseaseΑ-synuclein

Identifiers

PMID33772424
OpenAlexW3136211045

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.