Evidence map›Paper›PMID 33772384›Full record

ReviewMikrochimica acta2021

Novel devices for isolation and detection of bacterial and mammalian extracellular vesicles.

Shiana Malhotra, Zarinah M Amin, Garima Dobhal, Sophie Cottam, Thomas Nann, Renee V Goreham

Abstract readReview
PubMed Publisher
In one paragraph

Review in Mikrochimica acta, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Shiana MalhotraSchool of Mathematical and Physical Sciences, University of Newcastle, Callaghan, 2308, Australia.
Zarinah M AminSchool of Mathematical and Physical Sciences, University of Newcastle, Callaghan, 2308, Australia.
Garima DobhalSchool of Mathematical and Physical Sciences, University of Newcastle, Callaghan, 2308, Australia.
Sophie CottamSchool of Mathematical and Physical Sciences, University of Newcastle, Callaghan, 2308, Australia.
Thomas NannSchool of Mathematical and Physical Sciences, University of Newcastle, Callaghan, 2308, Australia.ORCID 0000-0002-2723-6553
Renee V GorehamSchool of Mathematical and Physical Sciences, University of Newcastle, Callaghan, 2308, Australia. renee.goreham@newcastle.edu.au.
University of Newcastle Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles are spherical nanoparticles inherently released by almost all cell types. They acquire the cell's membrane and cytoplasmic characteristics offering abundant identical units that can be captured to recognize the cell of origin. The abundance of vital cell information and multifunctional roles in cellular processes has rendered them attention, particularly as promising biomarkers for disease diagnosis and use in potential drug delivery systems. This review provides insights into standard approaches towards cultivation and isolation of mammalian and bacterial extracellular vesicles. We assess gaps in conventional separation and detection technologies while also tracking developments in ongoing research. The review focuses on highlighting alternative state-of-the-art microfluidic devices that offer avenues for fast, cost-effective, precision-oriented capture and sensing of extracellular vesicles. Combining different detection technologies on an integrated "lab-on-a-chip" system has the prospective to provide customizable opportunities for clinical use of extracellular vesicles in disease diagnostics and therapeutic applications.

Indexed as

Extracellular VesiclesAnimalsBacteriaBiosensing TechniquesHumansLab-On-A-Chip DevicesMicrofluidic Analytical TechniquesAcousticsAnalyticsElasticityExosomesImmunoaffinityMicrofluidicsNanoparticles

Identifiers

PMID33772384
OpenAlexW3137556877

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.