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ArticleClinical rheumatology2021

Rheumatoid arthritis in Colombia: a clinical profile and prevalence from a national registry.

Julieth Carolina Castillo-Cañón, Silvia Juliana Trujillo-Cáceres, Wilson Bautista-Molano, Ana María Valbuena-García, Daniel G Fernández-Ávila, Lizbeth Acuña-Merchán

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Clinical rheumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06915701 ("Evaluation of the Effect of Vitamin E), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06915701 phase2 / phase3recruitingnot on this mapstarted 2026, after this paper: background citation

"Evaluation of the Effect of Vitamin E (α-tocopherol) Supplementation on Clinical Activity and Inflammation in Patients With Rheumatoid Arthritis"

TypeinterventionalSponsorUniversity of GuadalajaraRan2026 to 2027Enrolled46ConditionsRheumatoid ArthritisArmsWill take vitamin E 800mg/day, Will take 200mg/day magnesium oxide placebo.
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Biomolecules & biomedicine · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Global epidemiology of rheumatoid arthritis.Nature reviews. Rheumatology · 2022
    Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Julieth Carolina Castillo-CañónHigh-Cost Disease Fund, Bogotá D.C., Colombia. Jcarolinacastillo15@gmail.com.
Silvia Juliana Trujillo-CáceresHigh-Cost Disease Fund, Bogotá D.C., Colombia.
Wilson Bautista-MolanoUniversity Hospital Fundación Santa Fe de Bogotá, Universidad El Bosque, Bogotá D.C., Colombia.
Ana María Valbuena-GarcíaHigh-Cost Disease Fund, Bogotá D.C., Colombia.
Daniel G Fernández-ÁvilaRheumatology Unit, Department of Internal Medicine, Hospital Universitario San Ignacio-School of Medicine, Pontificia Universidad Javeriana, Bogotá D.C., Colombia.
Lizbeth Acuña-MerchánHigh-Cost Disease Fund, Bogotá D.C., Colombia.
Fundación Santa Fe de Bogotá · COHospital Universitario San Ignacio · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is a need to describe the demographic and clinical characteristics of people diagnosed with rheumatoid arthritis who are attended within the Colombian health system. This characterization allows prioritizing populations with specific risks, programming the use of health services, and planning the costs necessary to guarantee equitable care.

objectiveTo assess the demographic and clinical characteristics of a cohort of patients with rheumatoid arthritis using national data collected by the High-Cost Disease Fund (CAC in Spanish).

methodsA cross-sectional study from a secondary source. Data was gathered from a national administrative registry. A descriptive analysis was performed on sociodemographic and clinical characteristics. Age-standardized prevalence was estimated at national level and by geographical regions. Remission rates were also estimated for Colombian departments and regions.

resultsBy 2019, 81,386 patients with rheumatoid arthritis were reported in Colombia. The relation female-male was 5.2:1. The median age was 59 years (IQR: 50-67). Prevalence was higher in people aged 50-69 years. The most frequent comorbidities were high blood pressure (31.15%) and osteoporosis (19.46%). Age-standardized prevalence of rheumatoid arthritis was 0.24 per 100 population (95% CI: 0.23-0.24). In cases with complete information, 57.57% of departments had remission rates up to 30%.

conclusionRheumatoid arthritis in Colombia was more frequent in females aged ≥50 year. Age-standardized prevalence was lower than reported by other studies performed in Colombia but similar to the estimated internationally for the country. Key Points • More than 80,000 rheumatoid arthritis patients were reported to this national registry in Colombia in 2019, finding an age-standardized prevalence of 0.24 per 100 population. • Hypertension was the most common comorbidity reported in people with rheumatoid arthritis. This finding is similar to the reports by similar studies such as the COMORA. • A major strength of this study is the large sample size since data come from a nationwide registry of people with rheumatoid arthritis, supported by the National Ministry of Health. Additionally, this registry has a rigorous data monitoring process that guarantees the internal validity of data and provides valuable information for decision-making based on local evidence. • Prevalence of rheumatoid arthritis was higher in females between 50 and 65 years. Age-standardized prevalence was lower than previously reported in Colombia, but similar to the world estimations.

Indexed as

Arthritis, RheumatoidColombiaCross-Sectional StudiesFemaleHumansMaleMiddle AgedPrevalenceRegistriesColombiaEpidemiologyLatin AmericaPrevalenceRegistriesRheumatoid arthritis

Identifiers

PMID33772350
OpenAlexW3138355875

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.