Evidence map›Paper›PMID 33772334›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2021

[

Marta Ferreira, Pierre Lovinfosse, Johanne Hermesse, Marjolein Decuypere, Caroline Rousseau, François Lucia, Ulrike Schick, Caroline Reinhold, Philippe Robin, Mathieu Hatt and 7 more

Erratum issuedAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Review
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  6. Review
  7. Article
  8. Development and validation of anAnnals of nuclear medicine · 2025
    Article
  9. Article
  10. IRMA: Machine learning-based harmonization ofEuropean journal of nuclear medicine and molecular imaging · 2025
    Article
  11. Review
  12. Article
  13. Observational
  14. Article
  15. [Diagnostics (Basel, Switzerland) · 2024
    Review
  16. Article
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  18. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Marta FerreiraGIGA-CRC in vivo Imaging, University of Liège, GIGA, Avenue de l'Hôpital 11, 4000, Liege, Belgium. m.Ferreira@student.uliege.be.
Pierre LovinfosseDivision of Nuclear Medicine and Oncological Imaging, University Hospital of Liège, Liège, Belgium.
Johanne HermesseDepartment of Radiation Oncology, Liège University Hospital, Liège, Belgium.
Marjolein DecuypereDivision of Oncological Gynecology, University Hospital of Liège, Liège, Belgium.
Caroline RousseauUniversité de Nantes, CNRS, Inserm, CRCINA, F-44000, Nantes, France.
François LuciaRadiation Oncology Department, University Hospital, Brest, France.
Ulrike SchickRadiation Oncology Department, University Hospital, Brest, France.
Caroline ReinholdDepartment of Radiology, McGill University Health Centre (MUHC), Montreal, Canada.
Philippe RobinDepartment of Nuclear Medicine and EA3878, Brest University Hospital, University of Brest, Brest, France.
Mathieu HattLaTIM, INSERM, UMR 1101, Univ Brest, Brest, France.
Dimitris VisvikisLaTIM, INSERM, UMR 1101, Univ Brest, Brest, France.
Claire BernardDivision of Nuclear Medicine and Oncological Imaging, University Hospital of Liège, Liège, Belgium.
Ralph T H LeijenaarOncoradiomics SA, Clos Chanmurly 13, 4000, Liège, Belgium.
Frédéric KridelkaDivision of Oncological Gynecology, University Hospital of Liège, Liège, Belgium.
Philippe LambinThe-D Lab, Precision Medicine, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, Netherlands.
Patrick E MeyerBioinformatics and Systems Biology Lab, University of Liège, Liège, Belgium.
Roland HustinxGIGA-CRC in vivo Imaging, University of Liège, GIGA, Avenue de l'Hôpital 11, 4000, Liege, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo test the performances of native and tumour to liver ratio (TLR) radiomic features extracted from pre-treatment 2-[

methodsOne hundred fifty-eight patients with LACC from multiple centers were retrospectively included in the study. Tumours were segmented using the Fuzzy Local Adaptive Bayesian (FLAB) algorithm. Radiomic features were extracted from the tumours and from regions drawn over the normal liver. Cox proportional hazard model was used to test statistical significance of clinical and radiomic features. Fivefold cross validation was used to tune the number of features. Seven different feature selection methods and four classifiers were tested. The models with the selected features were trained using bootstrapping and tested in data from each scanner independently. Reproducibility of radiomics features, clinical data added value and effect of ComBat-based harmonisation were evaluated across scanners.

resultsAfter a median follow-up of 23 months, 29% of the patients recurred. No individual radiomic or clinical features were significantly associated with cancer recurrence. The best model was obtained using 10 TLR features combined with clinical information. The area under the curve (AUC), F

conclusion[

Indexed as

Fluorodeoxyglucose F18Uterine Cervical NeoplasmsBayes TheoremDisease-Free SurvivalFemaleHumansNeoplasm Recurrence, LocalPositron Emission Tomography Computed TomographyRadiopharmaceuticalsReproducibility of ResultsRetrospective StudiesFluorodeoxyglucose F18Radiopharmaceuticals[18F]FDG PET/CTCervical cancerDisease-free survivalMachine learningRadiomics

Identifiers

PMID33772334
PMCPMC8440288

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.