ArticlePsychopharmacology2021
Association between functional brain alterations and neuropsychological scales in male chronic smokers using resting-state fMRI.
Article in Psychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- The resting-state brain activity signatures for addictive disorders.Med (New York, N.Y.) · 2024Pooled it
- Reduced Whole-Brain Network Segregation and Dorsal Anterior-Cingulate Cortex Neurochemical Alterations in Chronic Smokers.Brain and behavior · 2026Article
- Network localization of gray matter alterations in chronic smokers using the normative functional connectome.Frontiers in public health · 2026Article
- Individual-specific subspace of altered functional connectivity predicts clinical symptoms in Internet gaming disorder.Journal of behavioral addictions · 2025Article
- Abnormal resting-state effective connectivity of triple network predicts smoking motivations among males.Frontiers in psychiatry · 2025Article
- Correlation of N-acetylaspartyl glutamate level in the medial prefrontal cortex with FTND and daily smoking amounts in adult cigarette smokers.Frontiers in neuroscience · 2025Article
- Temporal and Spatial Analysis of Alzheimer's Disease Based on an Improved Convolutional Neural Network and a Resting-State FMRI Brain Functional Network.International journal of environmental research and public health · 2022Article
- Cognition, Aryl Hydrocarbon Receptor Repressor Methylation, and Abstinence Duration-Associated Multimodal Brain Networks in Smoking and Long-Term Smoking Cessation.Frontiers in neuroscience · 2022Article
- Brain Magnetic Resonance Imaging Features of Nicotine-Dependent Individuals and Its Correlation with Polymorphisms of Dopamine D Receptor Gene.Contrast media & molecular imaging · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleRecent studies have demonstrated that cigarette smoking is related to changes in brain structure and function. However, few studies focus on functional brain differences between male chronic smokers and nonsmokers in both local spontaneous activity and whole-brain functional networks.
objectivesOur study recruited 67 chronic smokers and 43 nonsmokers who underwent functional magnetic resonance imaging (fMRI) scans to investigate functional activity and connectivity alterations in chronic smokers.
methodsWe used the mean fractional amplitude of the low-frequency fluctuation (mfALFF) and mean regional homogeneity (mReHo) methods to investigate resting-state spontaneous activity in chronic smokers and nonsmokers. The graph theoretical analysis (GTA) and network-based statistical (NBS) analysis were also used to investigate functional connectivity alterations.
resultsCompared with nonsmokers, chronic smokers exhibited higher activation in the reward system and portions of the prefrontal cortex but lower activation in the default mode networks (DMN) and visual-related regions. In addition, correlation analysis was conducted to assess the associations between neuroimaging findings and the severity of nicotine dependence or expectations of smoking effects. Our results showed that certain brain regions correlated with the Fagerström Test for Nicotine Dependence (FTND), the positive aspect of the Drug Use Disorders Identification Test Extended (DUDIT-E), and the negative aspect of the DUDIT-E, especially in the attentional control networks and hippocampus. The graph theoretical analysis (GTA) results indicated chronic smokers exhibited a trend toward increased assortativity. Our network-based statistical (NBS) analysis revealed reduced functional connections between the subnetwork in the prefrontal cortex, olfactory cortex, angular gyrus, and cingulate gyrus of chronic smokers.
conclusionsWe concluded that chronic smokers have neural adaptations in local spontaneous activity but remain healthy brain functional networks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.