ArticleEuropean journal of preventive cardiology2022
The role of the electrocardiographic phenotype in risk stratification for sudden cardiac death in childhood hypertrophic cardiomyopathy.
Article in European journal of preventive cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Distinguishing athlete's heart from hypertrophic cardiomyopathy by ECG features in the pediatric population: a systematic review and meta-analysis.European journal of pediatrics · 2025Pooled it
- [Diagnostic and prognostic value of the resting ECG in structural heart disease].Herzschrittmachertherapie & Elektrophysiologie · 2026Review
- Characterisation and prognostic implications of the 12-lead electrocardiogram in children with RASopathy-associated hypertrophic cardiomyopathy.Heart (British Cardiac Society) · 2026Article
- Review
- Electrocardiographic Findings in Genotype-Positive and Non-sarcomeric Children with Definite Hypertrophic Cardiomyopathy and Subclinical Variant Carriers.Pediatric cardiology · 2024Article
- Utility and acceptability of remote 6-lead electrocardiographic monitoring in children with inherited cardiac conditions.Archives of disease in childhood · 2024Article
- Diagnostic and prognostic electrocardiographic features in patients with hypertrophic cardiomyopathy.European heart journal supplements : journal of the European Society of Cardiology · 2023Article
- Electrocardiographic Parameters Associated with Adverse Outcomes in Children with Cardiomyopathies.Journal of clinical medicine · 2022Article
- What Aspects of Phenotype Determine Risk for Sudden Cardiac Death in Pediatric Hypertrophic Cardiomyopathy?Journal of cardiovascular development and disease · 2022Review
- The use of attention-deficit hyperactivity disorder medications in cardiac disease.Frontiers in neuroscience · 2022Review
- Symptoms and ECG changes precede sudden cardiac death in hypertrophic cardiomyopathy-A nationwide study among the young in Sweden.PloS one · 2022Article
- Age-Related Electrocardiographic Characteristics of Male Junior Soccer Athletes.Frontiers in cardiovascular medicine · 2021Article
- Genetic Clues on Implantable Cardioverter-Defibrillator Placement in Young-Age Hypertrophic Cardiomyopathy: A Case Report of NovelFrontiers in cardiovascular medicine · 2021Article
- Childhood Hypertrophic Cardiomyopathy: A Disease of the Cardiac Sarcomere.Frontiers in pediatrics · 2021Review
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Authors and funding
51 authors at 20 institutions in 13 countries.
Funding
Abstract
aimsThe 12-lead electrocardiogram (ECG) is routinely performed in children with hypertrophic cardiomyopathy (HCM). An ECG risk score has been suggested as a useful tool for risk stratification, but this has not been independently validated. This aim of this study was to describe the ECG phenotype of childhood HCM in a large, international, multi-centre cohort and investigate its role in risk prediction for arrhythmic events. METHODS AND
resultsData from 356 childhood HCM patients with a mean age of 10.1 years (±4.5) were collected from a retrospective, multi-centre international cohort. Three hundred and forty-seven (97.5%) patients had ECG abnormalities at baseline, most commonly repolarization abnormalities (n = 277, 77.8%); left ventricular hypertrophy (n = 240, 67.7%); abnormal QRS axis (n = 126, 35.4%); or QT prolongation (n = 131, 36.8%). Over a median follow-up of 3.9 years (interquartile range 2.0-7.7), 25 (7%) had an arrhythmic event, with an overall annual event rate of 1.38 (95% CI 0.93-2.04). No ECG variables were associated with 5-year arrhythmic event on univariable or multivariable analysis. The ECG risk score threshold of >5 had modest discriminatory ability [C-index 0.60 (95% CI 0.484-0.715)], with corresponding negative and positive predictive values of 96.7% and 6.7.
conclusionIn a large, international, multi-centre cohort of childhood HCM, ECG abnormalities were common and varied. No ECG characteristic, either in isolation or combined in the previously described ECG risk score, was associated with 5-year sudden cardiac death risk. This suggests that the role of baseline ECG phenotype in improving risk stratification in childhood HCM is limited.
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