Evidence map›Paper›PMID 33772211›Full record

ArticleCommunications biology2021

Development of deep learning algorithms for predicting blastocyst formation and quality by time-lapse monitoring.

Qiuyue Liao, Qi Zhang, Xue Feng, Haibo Huang, Haohao Xu, Baoyuan Tian, Jihao Liu, Qihui Yu, Na Guo, Qun Liu and 5 more

Abstract read
In one paragraph

Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  7. From genes to germ layers: virtual twins of gastruloids.NPJ systems biology and applications · 2026
    Review
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  9. YOLO-VML: An Improved Object Detection Model for Blastomeres and Pronuclei Localization in IoMT.IEEE open journal of engineering in medicine and biology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Qiuyue Liao *Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.ORCID 0000-0001-8514-9792
Qi Zhang *Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, China.
Xue Feng *Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Haibo Huang *Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, China.
Haohao Xu *Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, China.
Baoyuan TianShanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, China.
Jihao LiuShanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, China.
Qihui YuShanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, China.
Na GuoDepartment of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Qun LiuDepartment of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Bo HuangDepartment of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Ding MaDepartment of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Jihui AiDepartment of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. jihuiai@tjh.tjmu.edu.cn.ORCID 0000-0002-1743-2980
Shugong XuShanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, China. shugong@shu.edu.cn.ORCID 0000-0003-1905-6269
Kezhen LiDepartment of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. tjkeke@126.com.ORCID 0000-0001-7943-5389

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Approaches to reliably predict the developmental potential of embryos and select suitable embryos for blastocyst culture are needed. The development of time-lapse monitoring (TLM) and artificial intelligence (AI) may help solve this problem. Here, we report deep learning models that can accurately predict blastocyst formation and usable blastocysts using TLM videos of the embryo's first three days. The DenseNet201 network, focal loss, long short-term memory (LSTM) network and gradient boosting classifier were mainly employed, and video preparation algorithms, spatial stream and temporal stream models were developed into ensemble prediction models called STEM and STEM

Indexed as

AlgorithmsDeep LearningEmbryonic DevelopmentTime-Lapse ImagingBlastocystHumans

Identifiers

PMID33772211
PMCPMC7998018

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.