Evidence map›Paper›PMID 33772095›Full record

ArticleNPJ digital medicine2021

Effectiveness of a digital therapeutic as adjunct to treatment with medication in pediatric ADHD.

Scott H Kollins, Ann Childress, Andrew C Heusser, Jacqueline Lutz

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ digital medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 54 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05435651 nacompletednot on this mapstarted 2022, after this paper: background citation

A Randomized Clinical Trial to Assess The Effectiveness and Safety of Digital Therapy for Treating Attention Deficit Hyperactivity Disorder in Children

TypeinterventionalSponsorChildren's Hospital of Fudan UniversityRan2022 to 2024Enrolled40ConditionsAttention Deficit Hyperactivity DisorderArmsMultitask game-based digital therapy, Schulte Grid digital game
NCT06140979 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Efficacy of Visual Focusing Game on Children With Attention Deficit Hyperactivity Disorder and Mechanisms of Functional Near-Infrared Spectroscopic Imaging

TypeinterventionalSponsorXijing HospitalRan2023 to 2024Enrolled40ConditionsAttention Deficit Hyperactivity DisorderArmsPlaying the game, Watching the gameplay video
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  10. A digital intervention for cognitive deficits following COVID-19: a randomized clinical trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Scott H KollinsDepartment of Psychiatry and Behavioral Sciences, Duke Clinical Research Institute, Duke University, Durham, NC, USA. scott.kollins@duke.edu.ORCID http://orcid.org/0000-0001-6847-6935
Ann ChildressCenter for Psychiatry and Behavioral Medicine, Las Vegas, NV, USA.
Andrew C HeusserAkili Interactive Laboratories, Boston, MA, USA.
Jacqueline LutzAkili Interactive Laboratories, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STARS-Adjunct was a multicenter, open-label effectiveness study of AKL-T01, an app and video-game-based treatment for inattention, as an adjunct to pharmacotherapy in 8-14-year-old children with attention-deficit/hyperactivity disorder (ADHD) on stimulant medication (n = 130) or not on any ADHD medication (n = 76). Children used AKL-T01 for 4 weeks, followed by a 4-week pause and another 4-week treatment. The primary outcome was change in ADHD-related impairment (Impairment Rating Scale (IRS)) after 4 weeks. Secondary outcomes included changes in IRS, ADHD Rating Scale (ADHD-RS). and Clinical Global Impressions Scale-Improvement (CGI-I) on days 28, 56, and 84. IRS significantly improved in both cohorts (On Stimulants: -0.7, p < 0.001; No Stimulants: -0.5, p < 0.001) after 4 weeks. IRS, ADHD-RS, and CGI-I remained stable during the pause and improved with a second treatment period. The treatment was well-tolerated with no serious adverse events. STARS-Adjunct extends AKL-T01's body of evidence to a medication-treated pediatric ADHD population, and suggests additional treatment benefit.

Identifiers

PMID33772095
PMCPMC7997870

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.