ArticleTranslational psychiatry2021
Pten is a key intrinsic factor regulating raphe 5-HT neuronal plasticity and depressive behaviors in mice.
Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- PTEN regulates starburst amacrine cell dendrite morphology during development.Development (Cambridge, England) · 2026Article
- Clinical implications of vasoactive intestinal peptide and 5-hydroxytryptamine in diabetic neurogenic bladder and their relationship with post-void residual.Journal of medical biochemistry · 2026Article
- Role of Genetic and Epigenetic Biomarkers in Treatment-Resistant Depression: A Literature Review.Genes · 2025Review
- G6PD deficiency in brain induces schizophrenia-like behaviors and synaptic dysfunction.Translational psychiatry · 2025Article
- Muscle-Derived miR-200a-3p Through Light-Intensity Exercise May Contribute to Improve Memory Dysfunction in Type 2 Diabetic Mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Effects of a 5-HTScientific reports · 2024Article
- Neural plasticity and depression treatment.IBRO neuroscience reports · 2023Article
- The Effects of Tai Chi on the Executive Functions and Physical Fitness in Middle-Aged Adults with Depression: A Randomized Controlled Trial.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Rnf220 is Implicated in the Dorsoventral Patterning of the Hindbrain Neural Tube in Mice.Frontiers in cell and developmental biology · 2022Article
- PTEN in prefrontal cortex is essential in regulating depression-like behaviors in mice.Translational psychiatry · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
Abstract
Serotonin (5-HT)-based antidepressants, selective serotonin reuptake inhibitors (SSRIs) aim to enhance serotonergic activity by blocking its reuptake. We propose PTEN as a target for an alternative approach for regulating 5-HT neuron activity in the brain and depressive behaviors. We show that PTEN is elevated in central 5-HT neurons in the raphe nucleus by chronic stress in mice, and selective deletion of Pten in the 5-HT neurons induces its structural plasticity shown by increases of dendritic branching and density of PSD95-positive puncta in the dendrites. 5-HT levels are elevated and electrical stimulation of raphe neurons evokes more 5-HT release in the brain of condition knockout (cKO) mice with Pten-deficient 5-HT neurons. In addition, the 5-HT neurons remain normal electrophysiological properties but have increased excitatory synaptic inputs. Single-cell RNA sequencing revealed gene transcript alterations that may underlay morphological and functional changes in Pten-deficient 5-HT neurons. Finally, Pten cKO mice and wild-type mice treated with systemic application of PTEN inhibitor display reduced depression-like behaviors. Thus, PTEN is an intrinsic regulator of 5-HT neuron activity, representing a novel therapeutic strategy for producing antidepressant action.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.