Evidence map›Paper›PMID 33771890›Full record

ArticleJournal for immunotherapy of cancer2021

Narrowband ultraviolet B therapy for refractory immune-related lichenoid dermatitis on PD-1 therapy: a case report.

Khashayar Esfahani, Meagan-Helen Henderson Berg, Hanieh Zargham, Robin Billick, Kevin Pehr, Margaret Redpath, Osama Roshdy, Wilson H Miller

Abstract readCase Reports
In one paragraph

Article in Journal for immunotherapy of cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Khashayar Esfahani *Division of Oncology, Department of Medicine, McGill University, Montreal, Quebec, Canada khashayar.esfahani@mcgill.ca.
Meagan-Helen Henderson Berg *Division of Dermatology, Department of Medicine, McGill University, Montreal, Quebec, Canada.ORCID 0000-0002-4622-2931
Hanieh ZarghamDivision of Dermatology, Department of Medicine, McGill University, Montreal, Quebec, Canada.
Robin BillickDivision of Dermatology, Department of Medicine, McGill University, Montreal, Quebec, Canada.
Kevin PehrDivision of Dermatology, Department of Medicine, McGill University, Montreal, Quebec, Canada.
Margaret RedpathDepartment of Pathology, McGill University, Montreal, Quebec, Canada.
Osama Roshdy *Division of Dermatology, Department of Medicine, McGill University, Montreal, Quebec, Canada.
Wilson H Miller *Division of Oncology, Department of Medicine, McGill University, Montreal, Quebec, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treatment with programmed cell death 1 inhibitors is associated with a wide range of cutaneous immune-related adverse events, with lichenoid eruptions representing one of the major cutaneous toxicities. We describe the case of an 81-year-old man with metastatic melanoma treated with pembrolizumab who subsequently developed a delayed-onset generalized lichenoid dermatitis. After failing multiple lines of systemic immunosuppression, narrowband ultraviolet B (NBUVB) phototherapy three times per week for 17 sessions resulted in a significant clinical response in his cutaneous eruption and was well tolerated. NBUVB is a safe, lower-cost modality that induces local, skin-specific immunosuppression without the toxicities of traditional systemic immunosuppressive agents. To date, this is the first report of use of NBUVB in immune-related lichenoid dermatitis resistant to multiple standard therapies.

Indexed as

Ultraviolet TherapyAged, 80 and overAntibodies, Monoclonal, HumanizedHumansImmune Checkpoint InhibitorsLichenoid EruptionsMaleMelanomaProgrammed Cell Death 1 ReceptorSkin NeoplasmsTreatment OutcomeAntibodies, Monoclonal, HumanizedImmune Checkpoint InhibitorsPDCD1 protein, humanpembrolizumabProgrammed Cell Death 1 Receptorautoimmunitycase reportsimmunotherapyinflammationmelanoma

Identifiers

PMID33771890
PMCPMC7996651

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.