ArticleScience immunology2021
A tumor-specific mechanism of T
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In one paragraph
Article in Science immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 26 citations in OpenAlex.
- Regulatory T cells in cancer and inflammation.Signal transduction and targeted therapy · 2026Review
- Diverse Biological Processes Contribute to Transforming Growth Factor β-Mediated Cancer Drug Resistance.Cells · 2025Review
- Biomechanics of the tumor extracellular matrix and regulatory T cells: regulatory mechanisms and potential therapeutic targets.Cell communication and signaling : CCS · 2025Review
- Article
- Regulatory T cells converted from Th1 cells in tumors suppress cancer immunity via CD39.The Journal of experimental medicine · 2025Article
- Blockade of αvβ6 and αvβ8 integrins with a chromogranin A-derived peptide inhibits TGFβ activation in tumors and suppresses tumor growth.Journal of experimental & clinical cancer research : CR · 2025Article
- Specifically blocking αvβ8-mediated TGF-β signaling to reverse immunosuppression by modulating macrophage polarization.Journal of experimental & clinical cancer research : CR · 2025Article
- Integrative multi-omics stratification and translational evaluation of Treg-targeted combination immunotherapy in breast cancer.Frontiers in oncology · 2025Article
- Article
- Regulatory T cell-mediated immunosuppression orchestrated by cancer: towards an immuno-genomic paradigm for precision medicine.Nature reviews. Clinical oncology · 2024Review
- Article
- Defining and using immune archetypes to classify and treat cancer.Nature reviews. Cancer · 2023Review
- TGFβ control of immune responses in cancer: a holistic immuno-oncology perspective.Nature reviews. Immunology · 2023Review
- Anti-GARP Antibodies Inhibit Release of TGF-β by Regulatory T Cells via Different Modes of Action, but Do Not Influence Their Function In Vitro.ImmunoHorizons · 2023Article
- Bispecific antibody targeting TGF-β and PD-L1 for synergistic cancer immunotherapy.Frontiers in immunology · 2023Review
- Article
- TGFβ activating integrins β6 and β8 are dysregulated in inflammatory skin disease and cutaneous melanoma.Journal of dermatological science · 2022Article
- Transforming growth factor-β1 in regulatory T cell biology.Science immunology · 2022Review
- Perinatal derivatives: How to best validate their immunomodulatory functions.Frontiers in bioengineering and biotechnology · 2022Review
- Clinical adoptive regulatory T Cell therapy: State of the art, challenges, and prospective.Frontiers in cell and developmental biology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 2 institutions in 1 country.
Robert I SeedDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94110, USA.ORCID 0000-0002-7588-9903
Kenji KobayashiDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94110, USA.ORCID 0000-0002-3908-2811
Saburo ItoDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94110, USA.
Naoki TakasakaDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94110, USA.ORCID 0000-0002-3016-233X
Anthony CormierDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94110, USA.ORCID 0000-0002-2848-9536
Jillian M JespersenDepartment of Medicine and Liver Center, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-8231-6978
Jean PublicoverDepartment of Medicine and Liver Center, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-8119-5414
Suprita TrilokDepartment of Medicine and Liver Center, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-7769-0957
Alexis J CombesDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94110, USA.ORCID 0000-0002-9110-6542
Nayvin W ChewDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94110, USA.
Jocelyne ChapmanDepartment of Gynecology and Oncology, University of California, San Francisco San Francisco, CA 94110, USA.ORCID 0000-0002-4260-3016
Matthew F KrummelDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94110, USA.ORCID 0000-0001-7915-3533
Jianlong LouDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA.
James MarksDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA.
Yifan ChengDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0001-9535-0369
Jody L BaronDepartment of Medicine and Liver Center, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0003-2799-9099
Stephen L NishimuraDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94110, USA. stephen.nishimura@ucsf.edu.ORCID 0000-0003-2312-4113
University of California, San Francisco · USHoward Hughes Medical Institute · US
Funding
UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7MUC BRAID Center for Accelerated Innovation COVID-19 diagnostic project developmentU54HL119893 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PALAZZOLO, MICHAEL J · 2013 to 2020
$18.3MMOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0MStructural mechanism of integrin-mediated TGF-b activationR01HL134183 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Yifan Cheng, Stephen L Nishimura · 2016 to 2026
$5.9MRenewable antibodies to secreted proteins and single and multi-pass cell surfaceP41CA196276 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRAIK, CHARLES SCOTT · 2014 to 2018
$5.8MIntegrating targeted and immunotherapy to treat genetically heterogeneous cancersU01CA217864 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BALMAIN, ALLAN, KRUMMEL, MATTHEW F · 2017 to 2021
$5.1MThe Tumor Microenvironment Niche of Type I conventional Dendritic CellsR01CA197363 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW F KRUMMEL · 2017 to 2026
$4.5MConformational regulation of TGF-β activation by integrin αvβ6R01HL165175 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Yifan Cheng, Stephen L Nishimura · 2023 to 2026
$3.2MRole of genetic variation in TGF-beta overactivation in COPDR01HL113032 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NISHIMURA, STEPHEN L · 2012 to 2015
$2.1MIdentifying and modulating therapeutic targets in a model of hepatitis BR01DK093646 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BARON, JODY L · 2012 to 2016
$1.7MIdentifying a role for commensal bacteria on the liver immune priming environmentK01DK099405 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PUBLICOVER, JEAN · 2013 to 2017
$715kLinux cluster for near atomic resolution single particle cryo-EMS10OD020054 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2015 to 2015
$456kHoward Hughes Medical InstituteNCI NIH HHS P41 CA196276NCI NIH HHS R01 CA197363NCI NIH HHS U01 CA217864NHLBI NIH HHS R01 HL113032NHLBI NIH HHS R01 HL134183NHLBI NIH HHS R01 HL165175NHLBI NIH HHS U54 HL119893NIAID NIH HHS T32 AI007334NIDDK NIH HHS F31 DK112607NIDDK NIH HHS K01 DK099405NIDDK NIH HHS P30 DK026743NIDDK NIH HHS R01 DK093646NIH HHS S10 OD020054
Abstract
Regulatory T cells (T
Indexed as
Tumor EscapeAnimalsBiomarkersCell Line, TumorComputational BiologyCytokinesDisease Models, AnimalDisease SusceptibilityGene Expression ProfilingHumansIntegrinsMiceModels, BiologicalNeoplasmsT-Lymphocytes, RegulatoryT-Lymphocyte SubsetsBiomarkersCytokinesintegrin alphavbeta8Integrins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.