ArticleScience advances2021
Multimerization variants as potential drivers of neofunctionalization.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Systems-level proteomic models of cotton fiber development: a high-resolution data resource to analyze cell dynamics and trait engineering.Plant physiology · 2026Article
- Discovery of regulatory complexes in Arabidopsis via protein-metabolite mapping during Pseudomonas infection.Plant physiology · 2026Article
- Ethylene reshapes protein assemblies in the dark.Plant physiology · 2025Article
- Mapping protein-metabolite interactions iniScience · 2025Article
- A high-resolution model of gene expression during Gossypium hirsutum (cotton) fiber development.BMC genomics · 2025Article
- Integrating CORUM and co-fractionation mass spectrometry to create enhanced benchmarks for protein complex predictions.Briefings in bioinformatics · 2025Article
- A cell fractionation and quantitative proteomics pipeline to enable functional analyses of cotton fiber development.The Plant journal : for cell and molecular biology · 2025Article
- The small protein MntS evolved from a signal peptide and acquired a novel function regulating manganese homeostasis in Escherichia coli.Molecular microbiology · 2024Article
- Genomic and Transcriptomic Insights into the Evolution and Divergence of MIKC-Type MADS-Box Genes inInternational journal of molecular sciences · 2023Article
- An actin remodeling role for Arabidopsis processing bodies revealed by their proximity interactome.The EMBO journal · 2023Article
- Exploring the genetic landscape of nitrogen uptake in durum wheat: genome-wide characterization and expression profiling of NPF and NRT2 gene families.Frontiers in plant science · 2023Article
- A co-fractionation mass spectrometry-based prediction of protein complex assemblies in the developing rice aleurone-subaleurone.The Plant cell · 2021Article
- Separated together: prediction of native protein complexes in rice aleurone via co-fractionation mass spectrometry.The Plant cell · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whole-genome duplications are common during evolution, creating genetic redundancy that can enable cellular innovations. Novel protein-protein interactions provide a route to diversified gene functions, but, at present, there is limited proteome-scale knowledge on the extent to which variability in protein complex formation drives neofunctionalization. Here, we used protein correlation profiling to test for variability in apparent mass among thousands of orthologous proteins isolated from diverse species and cell types. Variants in protein complex size were unexpectedly common, in some cases appearing after relatively recent whole-genome duplications or an allopolyploidy event. In other instances, variants such as those in the carbonic anhydrase orthologous group reflected the neofunctionalization of ancient paralogs that have been preserved in extant species. Our results demonstrate that homo- and heteromer formation have the potential to drive neofunctionalization in diverse classes of enzymes, signaling, and structural proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.